The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China

Background" Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that impairs a child’s ability to communicate with others. It also includes restricted repetitive behaviors, interests and activities. Symptoms manifest before the age of 3. In the previous studies, we found str...

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Autores principales:	Lv Meng-na, Zhang Hong, Shu Yi, Chen Shan, Hu Yuan-yuan, Zhou Min
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	autism spectrum disorder creatine kinase brain band isoenzyme neonatal behavioral assessment neuron-specific enolase total serum bilirubin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/695da4d6455c497da0b5ac1ff5adf36c
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spelling	oai:doaj.org-article:695da4d6455c497da0b5ac1ff5adf36c2021-12-05T14:11:04ZThe neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China2081-693610.1515/tnsci-2016-0002https://doaj.org/article/695da4d6455c497da0b5ac1ff5adf36c2016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0002https://doaj.org/toc/2081-6936Background" Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that impairs a child’s ability to communicate with others. It also includes restricted repetitive behaviors, interests and activities. Symptoms manifest before the age of 3. In the previous studies, we found structural abnormalities of the temporal lobe cortex. High spine densities were most commonly found in ASD subjects with lower levels of cognitive functioning. In the present study, we retrospectively analyzed medical records in relation to the neonatal levels of total serum bilirubin (TSB), neuron-specific enolase (NSE), creatine kinase brain band isoenzyme (CK-BB), and neonatal behavior in ASD patients from Southern China. Methods: A total of 80 patients with ASD (ASD group) were screened for this retrospective study. Among them, 34 were low-functioning ASD (L-ASD group) and 46 were high-functioning ASD (H-ASD group). Identification of the ASD cases was confirmed with a Revised Autism Diagnostic Inventory. For comparison with ASD cases, 80 normal neonates (control group) were selected from the same period. Biochemical parameters, including TSB, NSE and CK-BB in the neonatal period and medical records on neonatal behavior were collected. Results: The levels of serum TSB, NSE and CK-BB in the ASD group were significantly higher when compared with those from the control group (P < 0.01, or P < 0.05). The amounts of serum TSB, NSE and CK-BB in the L-ASD group were significantly higher when compared with those in the H-ASD group (P < 0.01, or P < 0.05). The Neonatal Behavioral Assessment Scale (NBAS) scores in the ASD group were significantly lower than that in the control group (P < 0.05). Likewise, the NBAS scores in the L-ASD group were significantly lower than that in the H-ASD group (P < 0.05). There was no association between serum TSB, NSE, CK-BB and NBAS scores (P > 0.05) in the ASD group. Conclusions: The neonatal levels of TSB, NSE and CK-BB in ASD from Southern China were significantly higher than those of healthy controls. These findings need to be investigated thoroughly by future studies with large sample.Lv Meng-naZhang HongShu YiChen ShanHu Yuan-yuanZhou MinDe Gruyterarticleautism spectrum disordercreatine kinase brain band isoenzymeneonatal behavioral assessmentneuron-specific enolasetotal serum bilirubinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 6-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder creatine kinase brain band isoenzyme neonatal behavioral assessment neuron-specific enolase total serum bilirubin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	autism spectrum disorder creatine kinase brain band isoenzyme neonatal behavioral assessment neuron-specific enolase total serum bilirubin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lv Meng-na Zhang Hong Shu Yi Chen Shan Hu Yuan-yuan Zhou Min The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China
description	Background" Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that impairs a child’s ability to communicate with others. It also includes restricted repetitive behaviors, interests and activities. Symptoms manifest before the age of 3. In the previous studies, we found structural abnormalities of the temporal lobe cortex. High spine densities were most commonly found in ASD subjects with lower levels of cognitive functioning. In the present study, we retrospectively analyzed medical records in relation to the neonatal levels of total serum bilirubin (TSB), neuron-specific enolase (NSE), creatine kinase brain band isoenzyme (CK-BB), and neonatal behavior in ASD patients from Southern China. Methods: A total of 80 patients with ASD (ASD group) were screened for this retrospective study. Among them, 34 were low-functioning ASD (L-ASD group) and 46 were high-functioning ASD (H-ASD group). Identification of the ASD cases was confirmed with a Revised Autism Diagnostic Inventory. For comparison with ASD cases, 80 normal neonates (control group) were selected from the same period. Biochemical parameters, including TSB, NSE and CK-BB in the neonatal period and medical records on neonatal behavior were collected. Results: The levels of serum TSB, NSE and CK-BB in the ASD group were significantly higher when compared with those from the control group (P < 0.01, or P < 0.05). The amounts of serum TSB, NSE and CK-BB in the L-ASD group were significantly higher when compared with those in the H-ASD group (P < 0.01, or P < 0.05). The Neonatal Behavioral Assessment Scale (NBAS) scores in the ASD group were significantly lower than that in the control group (P < 0.05). Likewise, the NBAS scores in the L-ASD group were significantly lower than that in the H-ASD group (P < 0.05). There was no association between serum TSB, NSE, CK-BB and NBAS scores (P > 0.05) in the ASD group. Conclusions: The neonatal levels of TSB, NSE and CK-BB in ASD from Southern China were significantly higher than those of healthy controls. These findings need to be investigated thoroughly by future studies with large sample.
format	article
author	Lv Meng-na Zhang Hong Shu Yi Chen Shan Hu Yuan-yuan Zhou Min
author_facet	Lv Meng-na Zhang Hong Shu Yi Chen Shan Hu Yuan-yuan Zhou Min
author_sort	Lv Meng-na
title	The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China
title_short	The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China
title_full	The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China
title_fullStr	The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China
title_full_unstemmed	The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China
title_sort	neonatal levels of tsb, nse and ck-bb in autism spectrum disorder from southern china
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/695da4d6455c497da0b5ac1ff5adf36c
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The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China

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