Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity

Abstract Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70% body weight (0.7 g). However...

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Autores principales:	Charlotte Richter, Bjoern Braunstein, Benjamin Staeudle, Julia Attias, Alexander Suess, Tobias Weber, Katya N. Mileva, Joern Rittweger, David A. Green, Kirsten Albracht
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/69640a606e9244de940655ed04c50852
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spelling	oai:doaj.org-article:69640a606e9244de940655ed04c508522021-12-02T18:50:53ZContractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity10.1038/s41526-021-00155-72373-8065https://doaj.org/article/69640a606e9244de940655ed04c508522021-08-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00155-7https://doaj.org/toc/2373-8065Abstract Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70% body weight (0.7 g). However, it has not been investigated how the reduced musculoskeletal loading affects muscle and series elastic element dynamics, and thereby force and power generation. Therefore, this study examined the effects of running on the vertical treadmill facility, a ground-based analog, at simulated 0.7 g on gastrocnemius medialis contractile behavior. The results reveal that fascicle−series elastic element behavior differs between simulated hypogravity and 1 g running. Whilst shorter peak series elastic element lengths at simulated 0.7 g appear to be the result of lower muscular and gravitational forces acting on it, increased fascicle lengths and decreased velocities could not be anticipated, but may inform the development of optimized running training in hypogravity. However, whether the alterations in contractile behavior precipitate musculoskeletal degeneration warrants further study.Charlotte RichterBjoern BraunsteinBenjamin StaeudleJulia AttiasAlexander SuessTobias WeberKatya N. MilevaJoern RittwegerDavid A. GreenKirsten AlbrachtNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Charlotte Richter Bjoern Braunstein Benjamin Staeudle Julia Attias Alexander Suess Tobias Weber Katya N. Mileva Joern Rittweger David A. Green Kirsten Albracht Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
description	Abstract Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70% body weight (0.7 g). However, it has not been investigated how the reduced musculoskeletal loading affects muscle and series elastic element dynamics, and thereby force and power generation. Therefore, this study examined the effects of running on the vertical treadmill facility, a ground-based analog, at simulated 0.7 g on gastrocnemius medialis contractile behavior. The results reveal that fascicle−series elastic element behavior differs between simulated hypogravity and 1 g running. Whilst shorter peak series elastic element lengths at simulated 0.7 g appear to be the result of lower muscular and gravitational forces acting on it, increased fascicle lengths and decreased velocities could not be anticipated, but may inform the development of optimized running training in hypogravity. However, whether the alterations in contractile behavior precipitate musculoskeletal degeneration warrants further study.
format	article
author	Charlotte Richter Bjoern Braunstein Benjamin Staeudle Julia Attias Alexander Suess Tobias Weber Katya N. Mileva Joern Rittweger David A. Green Kirsten Albracht
author_facet	Charlotte Richter Bjoern Braunstein Benjamin Staeudle Julia Attias Alexander Suess Tobias Weber Katya N. Mileva Joern Rittweger David A. Green Kirsten Albracht
author_sort	Charlotte Richter
title	Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
title_short	Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
title_full	Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
title_fullStr	Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
title_full_unstemmed	Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
title_sort	contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69640a606e9244de940655ed04c50852
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Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity

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