Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men

Abstract The aim of the study is to explore the longitudinal association of dietary acrylamide exposure with cognitive performance in Chinese elderly. The analysis was conducted among 2534 non-smoking elderly men and women based on a prospective study, Mr. and Ms. OS Hong Kong. Dietary acrylamide in...

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Autores principales:	Zhao-min Liu, Lap Ah Tse, Bailing Chen, Suyang Wu, Dicken Chan, Timothy Kowk, Jean Woo, Yu-Tao Xiang, Samuel Yeung-shan Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69695598caae48ceb0b9a07bb422222e
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spelling	oai:doaj.org-article:69695598caae48ceb0b9a07bb422222e2021-12-02T15:05:31ZDietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men10.1038/s41598-017-06813-92045-2322https://doaj.org/article/69695598caae48ceb0b9a07bb422222e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06813-9https://doaj.org/toc/2045-2322Abstract The aim of the study is to explore the longitudinal association of dietary acrylamide exposure with cognitive performance in Chinese elderly. The analysis was conducted among 2534 non-smoking elderly men and women based on a prospective study, Mr. and Ms. OS Hong Kong. Dietary acrylamide intake was assessed by food frequency questionnaires with data on local food contamination, derived from the first Hong Kong Total Diet Study. Global cognitive function was assessed by Cantonese version of Mini-Mental State Exam (MMSE) at the baseline and the 4th year of follow-up. Multivariable-adjusted linear and logistic regression models were used to assess the associations of dietary acrylamide with MMSE score changes or risk of poor cognition. The results indicated that among men with MMSE ≥ 18, each one SD increase of acrylamide decreased MMSE score by 7.698% (95%CI: −14.943%, −0.452%; p = 0.037). Logistic regression revealed an increased risk of poor cognition (MMSE ≤ 26) in men with HR of 3.356 (1.064~10.591, p = 0.039). The association became non-significance after further adjustment for telomere length. No significant association was observed in women. Dietary acrylamide exposure was associated with a mild cognitive decline or increased risk of poor cognition over a 4-year period in non-smoking Chinese elderly men.Zhao-min LiuLap Ah TseBailing ChenSuyang WuDicken ChanTimothy KowkJean WooYu-Tao XiangSamuel Yeung-shan WongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhao-min Liu Lap Ah Tse Bailing Chen Suyang Wu Dicken Chan Timothy Kowk Jean Woo Yu-Tao Xiang Samuel Yeung-shan Wong Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men
description	Abstract The aim of the study is to explore the longitudinal association of dietary acrylamide exposure with cognitive performance in Chinese elderly. The analysis was conducted among 2534 non-smoking elderly men and women based on a prospective study, Mr. and Ms. OS Hong Kong. Dietary acrylamide intake was assessed by food frequency questionnaires with data on local food contamination, derived from the first Hong Kong Total Diet Study. Global cognitive function was assessed by Cantonese version of Mini-Mental State Exam (MMSE) at the baseline and the 4th year of follow-up. Multivariable-adjusted linear and logistic regression models were used to assess the associations of dietary acrylamide with MMSE score changes or risk of poor cognition. The results indicated that among men with MMSE ≥ 18, each one SD increase of acrylamide decreased MMSE score by 7.698% (95%CI: −14.943%, −0.452%; p = 0.037). Logistic regression revealed an increased risk of poor cognition (MMSE ≤ 26) in men with HR of 3.356 (1.064~10.591, p = 0.039). The association became non-significance after further adjustment for telomere length. No significant association was observed in women. Dietary acrylamide exposure was associated with a mild cognitive decline or increased risk of poor cognition over a 4-year period in non-smoking Chinese elderly men.
format	article
author	Zhao-min Liu Lap Ah Tse Bailing Chen Suyang Wu Dicken Chan Timothy Kowk Jean Woo Yu-Tao Xiang Samuel Yeung-shan Wong
author_facet	Zhao-min Liu Lap Ah Tse Bailing Chen Suyang Wu Dicken Chan Timothy Kowk Jean Woo Yu-Tao Xiang Samuel Yeung-shan Wong
author_sort	Zhao-min Liu
title	Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men
title_short	Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men
title_full	Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men
title_fullStr	Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men
title_full_unstemmed	Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men
title_sort	dietary acrylamide exposure was associated with mild cognition decline among non-smoking chinese elderly men
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/69695598caae48ceb0b9a07bb422222e
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Dietary acrylamide exposure was associated with mild cognition decline among non-smoking Chinese elderly men

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