Correlation of biochemical profile at admission with severity and outcome of COVID-19

Background COVID-19 was detected in China in December 2019. The rapid dissemination and novelty of the disease resulted in an epidemic. This study aimed to identify biochemical parameters at admission that can be used to categorize severity and outcome of COVID −19 infection. Materials and Methods T...

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Autores principales:	Abdullah Sadiq, Muhammad Khurram, Javaria Malik, Noman Ahmed Chaudhary, Muhammad Mujeeb Khan, Tahira Yasmeen, Hamza Waqar Bhatti
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	coronavirus alanine aminotransferase aspartate aminotransferase urea sodium Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/696af91c745f4532a8453a521f43f5c2
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spelling	oai:doaj.org-article:696af91c745f4532a8453a521f43f5c22021-11-17T14:21:57ZCorrelation of biochemical profile at admission with severity and outcome of COVID-192000-966610.1080/20009666.2021.1974161https://doaj.org/article/696af91c745f4532a8453a521f43f5c22021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/20009666.2021.1974161https://doaj.org/toc/2000-9666Background COVID-19 was detected in China in December 2019. The rapid dissemination and novelty of the disease resulted in an epidemic. This study aimed to identify biochemical parameters at admission that can be used to categorize severity and outcome of COVID −19 infection. Materials and Methods This cross-sectional study was conducted at Allied Hospitals of RMU from April 2020 to July 2020. It included 128 randomly selected confirmed COVID-19 patients. At admission, biochemical profile (total bilirubin, alanine aminotransferases {ALT}, aspartate aminotransferases {AST}, urea, creatinine, uric acid, sodium, potassium, and chloride were correlated with severity and outcome of COVID-19 by employing t-tests and ANOVA where required. Cut-off values to predict disease severity and outcome were calculated using ROC curve. Results The study comprised 46.1% non-severe, 29.7% severe, and 24.2% critical COVID-19 patients. 84.4% patients improved and 15.6% expired. Urea was increased in critical disease patients (p < 0.000). Higher ALT (p 0.030) and AST (p 0.004) levels were noted in severe and critical disease. Sodium (p 0.001) and chloride (p 0.026) were decreased in critical disease. Patients who expired had increased urea (p 0.000), ALT (p 0.040) and AST (p 0.002). At admission, urea >42.7 mg (sensitivity of 64.7%, specificity of 87.5%), AST >43.5 IU/L (64% sensitivity, 60% specificity), and sodium <136.9 mmol/L (sensitivity of 70.6%, specificity of 71.2%) predicted critical COVID-19 infection. Conclusion At admission, increased urea, AST, and ALT along with decreased sodium can help in identifying COVID-19 patients with severe illness and poor outcome.Abdullah SadiqMuhammad KhurramJavaria MalikNoman Ahmed ChaudharyMuhammad Mujeeb KhanTahira YasmeenHamza Waqar BhattiTaylor & Francis Grouparticlecoronavirusalanine aminotransferaseaspartate aminotransferaseureasodiumInternal medicineRC31-1245ENJournal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 740-746 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronavirus alanine aminotransferase aspartate aminotransferase urea sodium Internal medicine RC31-1245
spellingShingle	coronavirus alanine aminotransferase aspartate aminotransferase urea sodium Internal medicine RC31-1245 Abdullah Sadiq Muhammad Khurram Javaria Malik Noman Ahmed Chaudhary Muhammad Mujeeb Khan Tahira Yasmeen Hamza Waqar Bhatti Correlation of biochemical profile at admission with severity and outcome of COVID-19
description	Background COVID-19 was detected in China in December 2019. The rapid dissemination and novelty of the disease resulted in an epidemic. This study aimed to identify biochemical parameters at admission that can be used to categorize severity and outcome of COVID −19 infection. Materials and Methods This cross-sectional study was conducted at Allied Hospitals of RMU from April 2020 to July 2020. It included 128 randomly selected confirmed COVID-19 patients. At admission, biochemical profile (total bilirubin, alanine aminotransferases {ALT}, aspartate aminotransferases {AST}, urea, creatinine, uric acid, sodium, potassium, and chloride were correlated with severity and outcome of COVID-19 by employing t-tests and ANOVA where required. Cut-off values to predict disease severity and outcome were calculated using ROC curve. Results The study comprised 46.1% non-severe, 29.7% severe, and 24.2% critical COVID-19 patients. 84.4% patients improved and 15.6% expired. Urea was increased in critical disease patients (p < 0.000). Higher ALT (p 0.030) and AST (p 0.004) levels were noted in severe and critical disease. Sodium (p 0.001) and chloride (p 0.026) were decreased in critical disease. Patients who expired had increased urea (p 0.000), ALT (p 0.040) and AST (p 0.002). At admission, urea >42.7 mg (sensitivity of 64.7%, specificity of 87.5%), AST >43.5 IU/L (64% sensitivity, 60% specificity), and sodium <136.9 mmol/L (sensitivity of 70.6%, specificity of 71.2%) predicted critical COVID-19 infection. Conclusion At admission, increased urea, AST, and ALT along with decreased sodium can help in identifying COVID-19 patients with severe illness and poor outcome.
format	article
author	Abdullah Sadiq Muhammad Khurram Javaria Malik Noman Ahmed Chaudhary Muhammad Mujeeb Khan Tahira Yasmeen Hamza Waqar Bhatti
author_facet	Abdullah Sadiq Muhammad Khurram Javaria Malik Noman Ahmed Chaudhary Muhammad Mujeeb Khan Tahira Yasmeen Hamza Waqar Bhatti
author_sort	Abdullah Sadiq
title	Correlation of biochemical profile at admission with severity and outcome of COVID-19
title_short	Correlation of biochemical profile at admission with severity and outcome of COVID-19
title_full	Correlation of biochemical profile at admission with severity and outcome of COVID-19
title_fullStr	Correlation of biochemical profile at admission with severity and outcome of COVID-19
title_full_unstemmed	Correlation of biochemical profile at admission with severity and outcome of COVID-19
title_sort	correlation of biochemical profile at admission with severity and outcome of covid-19
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/696af91c745f4532a8453a521f43f5c2
work_keys_str_mv	AT abdullahsadiq correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT muhammadkhurram correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT javariamalik correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT nomanahmedchaudhary correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT muhammadmujeebkhan correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT tahirayasmeen correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT hamzawaqarbhatti correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19
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Correlation of biochemical profile at admission with severity and outcome of COVID-19

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