Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures

Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, authors develop ultrasoft sensors that visibly deform under cell-generated stress to capture patterns of internal stress development during multicellular spheroi...

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Autores principales:	Wontae Lee, Nikita Kalashnikov, Stephanie Mok, Ruba Halaoui, Elena Kuzmin, Andrew J. Putnam, Shuichi Takayama, Morag Park, Luke McCaffrey, Ruogang Zhao, Richard L. Leask, Christopher Moraes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/696b9e064eb14227b3aba6204e420d6c
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spelling	oai:doaj.org-article:696b9e064eb14227b3aba6204e420d6c2021-12-02T16:58:17ZDispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures10.1038/s41467-018-07967-42041-1723https://doaj.org/article/696b9e064eb14227b3aba6204e420d6c2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07967-4https://doaj.org/toc/2041-1723Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, authors develop ultrasoft sensors that visibly deform under cell-generated stress to capture patterns of internal stress development during multicellular spheroid formation.Wontae LeeNikita KalashnikovStephanie MokRuba HalaouiElena KuzminAndrew J. PutnamShuichi TakayamaMorag ParkLuke McCaffreyRuogang ZhaoRichard L. LeaskChristopher MoraesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wontae Lee Nikita Kalashnikov Stephanie Mok Ruba Halaoui Elena Kuzmin Andrew J. Putnam Shuichi Takayama Morag Park Luke McCaffrey Ruogang Zhao Richard L. Leask Christopher Moraes Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
description	Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, authors develop ultrasoft sensors that visibly deform under cell-generated stress to capture patterns of internal stress development during multicellular spheroid formation.
format	article
author	Wontae Lee Nikita Kalashnikov Stephanie Mok Ruba Halaoui Elena Kuzmin Andrew J. Putnam Shuichi Takayama Morag Park Luke McCaffrey Ruogang Zhao Richard L. Leask Christopher Moraes
author_facet	Wontae Lee Nikita Kalashnikov Stephanie Mok Ruba Halaoui Elena Kuzmin Andrew J. Putnam Shuichi Takayama Morag Park Luke McCaffrey Ruogang Zhao Richard L. Leask Christopher Moraes
author_sort	Wontae Lee
title	Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
title_short	Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
title_full	Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
title_fullStr	Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
title_full_unstemmed	Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
title_sort	dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/696b9e064eb14227b3aba6204e420d6c
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Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures

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