Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

Sarcopenia is the age-associated functional decline and atrophy of muscle fibers, and it has been proposed that it might be counteracted by inducing myofiber hypertrophy. Here, the authors show that expression levels of the ubiquitin ligase UBR4 are increased with ageing, and that whilst its genetic...

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Autores principales:	Liam C. Hunt, Bronwen Schadeberg, Jared Stover, Benard Haugen, Vishwajeeth Pagala, Yong-Dong Wang, Jason Puglise, Elisabeth R. Barton, Junmin Peng, Fabio Demontis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/696daac57df34ee1ab4b69517f4a1f99
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spelling	oai:doaj.org-article:696daac57df34ee1ab4b69517f4a1f992021-12-02T15:52:44ZAntagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging10.1038/s41467-021-21738-82041-1723https://doaj.org/article/696daac57df34ee1ab4b69517f4a1f992021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21738-8https://doaj.org/toc/2041-1723Sarcopenia is the age-associated functional decline and atrophy of muscle fibers, and it has been proposed that it might be counteracted by inducing myofiber hypertrophy. Here, the authors show that expression levels of the ubiquitin ligase UBR4 are increased with ageing, and that whilst its genetic ablation rescues muscle atrophy, it is also associated with reduced protein quality and impaired force production in Drosophila and mouse models.Liam C. HuntBronwen SchadebergJared StoverBenard HaugenVishwajeeth PagalaYong-Dong WangJason PugliseElisabeth R. BartonJunmin PengFabio DemontisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liam C. Hunt Bronwen Schadeberg Jared Stover Benard Haugen Vishwajeeth Pagala Yong-Dong Wang Jason Puglise Elisabeth R. Barton Junmin Peng Fabio Demontis Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
description	Sarcopenia is the age-associated functional decline and atrophy of muscle fibers, and it has been proposed that it might be counteracted by inducing myofiber hypertrophy. Here, the authors show that expression levels of the ubiquitin ligase UBR4 are increased with ageing, and that whilst its genetic ablation rescues muscle atrophy, it is also associated with reduced protein quality and impaired force production in Drosophila and mouse models.
format	article
author	Liam C. Hunt Bronwen Schadeberg Jared Stover Benard Haugen Vishwajeeth Pagala Yong-Dong Wang Jason Puglise Elisabeth R. Barton Junmin Peng Fabio Demontis
author_facet	Liam C. Hunt Bronwen Schadeberg Jared Stover Benard Haugen Vishwajeeth Pagala Yong-Dong Wang Jason Puglise Elisabeth R. Barton Junmin Peng Fabio Demontis
author_sort	Liam C. Hunt
title	Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
title_short	Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
title_full	Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
title_fullStr	Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
title_full_unstemmed	Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
title_sort	antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase ubr4 during aging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/696daac57df34ee1ab4b69517f4a1f99
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Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

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