Prosaposin is a regulator of progranulin levels and oligomerization

Increasing progranulin (PGRN) levels is a promising approach for treating frontotemporal dementia and other neurodegenerative diseases. Here Nicholson et al.show that the prosaposin (PSAP) locus is associated with plasma PGRN levels and demonstrate that PSAP can alter PGRN levels and its oligomeriza...

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Autores principales:	Alexandra M. Nicholson, NiCole A. Finch, Marcio Almeida, Ralph B. Perkerson, Marka van Blitterswijk, Aleksandra Wojtas, Basar Cenik, Sergio Rotondo, Venette Inskeep, Laura Almasy, Thomas Dyer, Juan Peralta, Goo Jun, Andrew R. Wood, Timothy M. Frayling, Christian Fuchsberger, Sharon Fowler, Tanya M. Teslovich, Alisa K. Manning, Satish Kumar, Joanne Curran, Donna Lehman, Goncalo Abecasis, Ravindranath Duggirala, Cyril Pottier, Haaris A. Zahir, Julia E. Crook, Anna Karydas, Laura Mitic, Ying Sun, Dennis W. Dickson, Guojun Bu, Joachim Herz, Gang Yu, Bruce L. Miller, Shawn Ferguson, Ronald C. Petersen, Neill Graff-Radford, John Blangero, Rosa Rademakers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69727bed9cd74c41b1fff7349a1c4efe
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spelling	oai:doaj.org-article:69727bed9cd74c41b1fff7349a1c4efe2021-12-02T17:33:10ZProsaposin is a regulator of progranulin levels and oligomerization10.1038/ncomms119922041-1723https://doaj.org/article/69727bed9cd74c41b1fff7349a1c4efe2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11992https://doaj.org/toc/2041-1723Increasing progranulin (PGRN) levels is a promising approach for treating frontotemporal dementia and other neurodegenerative diseases. Here Nicholson et al.show that the prosaposin (PSAP) locus is associated with plasma PGRN levels and demonstrate that PSAP can alter PGRN levels and its oligomerization.Alexandra M. NicholsonNiCole A. FinchMarcio AlmeidaRalph B. PerkersonMarka van BlitterswijkAleksandra WojtasBasar CenikSergio RotondoVenette InskeepLaura AlmasyThomas DyerJuan PeraltaGoo JunAndrew R. WoodTimothy M. FraylingChristian FuchsbergerSharon FowlerTanya M. TeslovichAlisa K. ManningSatish KumarJoanne CurranDonna LehmanGoncalo AbecasisRavindranath DuggiralaCyril PottierHaaris A. ZahirJulia E. CrookAnna KarydasLaura MiticYing SunDennis W. DicksonGuojun BuJoachim HerzGang YuBruce L. MillerShawn FergusonRonald C. PetersenNeill Graff-RadfordJohn BlangeroRosa RademakersNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra M. Nicholson NiCole A. Finch Marcio Almeida Ralph B. Perkerson Marka van Blitterswijk Aleksandra Wojtas Basar Cenik Sergio Rotondo Venette Inskeep Laura Almasy Thomas Dyer Juan Peralta Goo Jun Andrew R. Wood Timothy M. Frayling Christian Fuchsberger Sharon Fowler Tanya M. Teslovich Alisa K. Manning Satish Kumar Joanne Curran Donna Lehman Goncalo Abecasis Ravindranath Duggirala Cyril Pottier Haaris A. Zahir Julia E. Crook Anna Karydas Laura Mitic Ying Sun Dennis W. Dickson Guojun Bu Joachim Herz Gang Yu Bruce L. Miller Shawn Ferguson Ronald C. Petersen Neill Graff-Radford John Blangero Rosa Rademakers Prosaposin is a regulator of progranulin levels and oligomerization
description	Increasing progranulin (PGRN) levels is a promising approach for treating frontotemporal dementia and other neurodegenerative diseases. Here Nicholson et al.show that the prosaposin (PSAP) locus is associated with plasma PGRN levels and demonstrate that PSAP can alter PGRN levels and its oligomerization.
format	article
author	Alexandra M. Nicholson NiCole A. Finch Marcio Almeida Ralph B. Perkerson Marka van Blitterswijk Aleksandra Wojtas Basar Cenik Sergio Rotondo Venette Inskeep Laura Almasy Thomas Dyer Juan Peralta Goo Jun Andrew R. Wood Timothy M. Frayling Christian Fuchsberger Sharon Fowler Tanya M. Teslovich Alisa K. Manning Satish Kumar Joanne Curran Donna Lehman Goncalo Abecasis Ravindranath Duggirala Cyril Pottier Haaris A. Zahir Julia E. Crook Anna Karydas Laura Mitic Ying Sun Dennis W. Dickson Guojun Bu Joachim Herz Gang Yu Bruce L. Miller Shawn Ferguson Ronald C. Petersen Neill Graff-Radford John Blangero Rosa Rademakers
author_facet	Alexandra M. Nicholson NiCole A. Finch Marcio Almeida Ralph B. Perkerson Marka van Blitterswijk Aleksandra Wojtas Basar Cenik Sergio Rotondo Venette Inskeep Laura Almasy Thomas Dyer Juan Peralta Goo Jun Andrew R. Wood Timothy M. Frayling Christian Fuchsberger Sharon Fowler Tanya M. Teslovich Alisa K. Manning Satish Kumar Joanne Curran Donna Lehman Goncalo Abecasis Ravindranath Duggirala Cyril Pottier Haaris A. Zahir Julia E. Crook Anna Karydas Laura Mitic Ying Sun Dennis W. Dickson Guojun Bu Joachim Herz Gang Yu Bruce L. Miller Shawn Ferguson Ronald C. Petersen Neill Graff-Radford John Blangero Rosa Rademakers
author_sort	Alexandra M. Nicholson
title	Prosaposin is a regulator of progranulin levels and oligomerization
title_short	Prosaposin is a regulator of progranulin levels and oligomerization
title_full	Prosaposin is a regulator of progranulin levels and oligomerization
title_fullStr	Prosaposin is a regulator of progranulin levels and oligomerization
title_full_unstemmed	Prosaposin is a regulator of progranulin levels and oligomerization
title_sort	prosaposin is a regulator of progranulin levels and oligomerization
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/69727bed9cd74c41b1fff7349a1c4efe
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Prosaposin is a regulator of progranulin levels and oligomerization

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