Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

JingLun Li,1 JiaoJiao Deng,2 JinXian Yuan,1 Jie Fu,1 XiaoLing Li,2 AiPing Tong,2 YueLong Wang,2 YangMei Chen,1 Gang Guo2 1Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 2State Key Laboratory of Biotherapy and Cancer Center, and Department of Neur...

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Autores principales:	Li JL, Deng JJ, Yuan JX, Fu J, Li XL, Tong AP, Wang YL, Chen YM, Guo G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Spinal cord injury zonisamide nano-micelles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/69735de2b5d644248169ec6983b01b0a
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spelling	oai:doaj.org-article:69735de2b5d644248169ec6983b01b0a2021-12-02T01:32:10ZZonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury1178-2013https://doaj.org/article/69735de2b5d644248169ec6983b01b0a2017-03-01T00:00:00Zhttps://www.dovepress.com/zonisamide-loaded-triblock-copolymer-nanomicelles-as-a-novel-drug-deli-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013JingLun Li,1 JiaoJiao Deng,2 JinXian Yuan,1 Jie Fu,1 XiaoLing Li,2 AiPing Tong,2 YueLong Wang,2 YangMei Chen,1 Gang Guo2 1Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 2State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China Abstract: Spinal cord injury (SCI) commonly leads to lifelong disability due to the limited regenerative capacity of the adult central nervous system. Nanomicelles can be used as therapeutic systems to provide effective treatments for SCI. In this study, a novel triblock monomethyl poly(ethylene glycol)-poly(L-lactide)-poly(trimethylene carbonate) copolymer was successfully synthesized. Next, polymeric nanomicelles loaded with zonisamide (ZNS), a Food and Drug Administration-approved antiepileptic drug, were prepared and characterized. The ZNS-loaded micelles (ZNS-M) were further utilized for the treatment of SCI in vitro and in vivo. The obtained ZNS-M were ~50 nm in diameter with good solubility and dispersibility. Additionally, these controlled-release micelles showed significant antioxidative and neuron-protective effects in vitro. Finally, our results indicated that ZNS-M treatment could promote motor function recovery and could increase neuron and axon density in a hemisection SCI model. In summary, these results may provide an experimental basis for the use of ZNS-M as a clinically applicable therapeutic drug for the treatment of SCI in the future. Keywords: spinal cord injury, zonisamide, nanomicellesLi JLDeng JJYuan JXFu JLi XLTong APWang YLChen YMGuo GDove Medical PressarticleSpinal cord injuryzonisamidenano-micellesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2443-2456 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spinal cord injury zonisamide nano-micelles Medicine (General) R5-920
spellingShingle	Spinal cord injury zonisamide nano-micelles Medicine (General) R5-920 Li JL Deng JJ Yuan JX Fu J Li XL Tong AP Wang YL Chen YM Guo G Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
description	JingLun Li,1 JiaoJiao Deng,2 JinXian Yuan,1 Jie Fu,1 XiaoLing Li,2 AiPing Tong,2 YueLong Wang,2 YangMei Chen,1 Gang Guo2 1Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 2State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China Abstract: Spinal cord injury (SCI) commonly leads to lifelong disability due to the limited regenerative capacity of the adult central nervous system. Nanomicelles can be used as therapeutic systems to provide effective treatments for SCI. In this study, a novel triblock monomethyl poly(ethylene glycol)-poly(L-lactide)-poly(trimethylene carbonate) copolymer was successfully synthesized. Next, polymeric nanomicelles loaded with zonisamide (ZNS), a Food and Drug Administration-approved antiepileptic drug, were prepared and characterized. The ZNS-loaded micelles (ZNS-M) were further utilized for the treatment of SCI in vitro and in vivo. The obtained ZNS-M were ~50 nm in diameter with good solubility and dispersibility. Additionally, these controlled-release micelles showed significant antioxidative and neuron-protective effects in vitro. Finally, our results indicated that ZNS-M treatment could promote motor function recovery and could increase neuron and axon density in a hemisection SCI model. In summary, these results may provide an experimental basis for the use of ZNS-M as a clinically applicable therapeutic drug for the treatment of SCI in the future. Keywords: spinal cord injury, zonisamide, nanomicelles
format	article
author	Li JL Deng JJ Yuan JX Fu J Li XL Tong AP Wang YL Chen YM Guo G
author_facet	Li JL Deng JJ Yuan JX Fu J Li XL Tong AP Wang YL Chen YM Guo G
author_sort	Li JL
title	Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
title_short	Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
title_full	Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
title_fullStr	Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
title_full_unstemmed	Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
title_sort	zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/69735de2b5d644248169ec6983b01b0a
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Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

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