Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia

Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia

Saeed Kadasah,1 Misbahul Arfin,2 Sadaf Rizvi,2 Mohammed Al-Asmari,2 Abdulrahman Al-Asmari2 1Department of Psychiatry, 2Division of Molecular Biology & Genetics, Scientific Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia Background: Schizophrenia is one o...

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Autores principales: Kadasah S, Arfin M, Rizvi S, Al-Asmari M, Al-Asmari A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
schizophrenia
tumor necrosis factor (TNF)
gene polymorphism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/6977ef8dc19e4504bce7b6ec61544128
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spelling oai:doaj.org-article:6977ef8dc19e4504bce7b6ec615441282021-12-02T11:32:15ZTumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia1178-2021https://doaj.org/article/6977ef8dc19e4504bce7b6ec615441282017-04-01T00:00:00Zhttps://www.dovepress.com/tumor-necrosis-factor-alpha-and--beta-genetic-polymorphisms-as-a-risk--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Saeed Kadasah,1 Misbahul Arfin,2 Sadaf Rizvi,2 Mohammed Al-Asmari,2 Abdulrahman Al-Asmari2 1Department of Psychiatry, 2Division of Molecular Biology & Genetics, Scientific Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia Background: Schizophrenia is one of the most common devastating psychiatric disorders that negatively affects the quality of life and psychosocial functions. Its etiology involves the interplay of complex polygenic influences and environmental risk factors. Inflammatory markers are well-known etiological factors for psychiatric disorders, including schizophrenia. Objective: The aim of this study was to investigate the association of proinflammatory cytokine genes, tumor necrosis factor (TNF)-α (-308G/A) and TNF-β (+252A/G) polymorphisms with schizophrenia susceptibility. Subjects and methods: TNF-α and TNF-β genes were amplified using amplification refractory mutation system primers in 180 schizophrenia patients and 200 healthy matched controls recruited from the Psychiatry Clinic of Prince Sultan Military Medical City, Riyadh. The frequencies of alleles and genotypes of TNF-α (-308G/A) and TNF-β (+252A/G) polymorphisms in patients were compared with those in controls. Results: The frequencies of TNF-α (-308) allele A and genotype GA were significantly higher, while those of allele G and genotype GG were lower in schizophrenia patients as compared to controls, indicating that genotype GA and allele A of TNF-α (-308G/A) may increase susceptibility to schizophrenia, while genotype GG and allele G may reduce it. On the other hand, the distribution of alleles and genotypes of TNF-β (+252A/G) polymorphism does not differ significantly in patients from controls; however, the frequency of genotype GG of TNF-β (+252A/G) was significantly higher in male patients than in female patients. The distribution of TNF-α (-308G/A) and TNF-β (+252A/G) polymorphisms was almost similar in schizophrenia patients with negative or positive symptoms. Conclusion: TNF-α (-308G/A) and TNF-β (+252G/A) polymorphisms may increase the susceptibility to schizophrenia in Saudi patients and could be a potential risk factor for its etiopathogenesis. However, further studies are warranted involving a larger sample size to strengthen our findings. Keywords: schizophrenia, tumor necrosis factor, gene polymorphism, genetics, psychiatric disorderKadasah SArfin MRizvi SAl-Asmari MAl-Asmari ADove Medical Pressarticleschizophreniatumor necrosis factor (TNF)gene polymorphismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1081-1088 (2017)
institution DOAJ
collection DOAJ
language EN
topic schizophrenia
tumor necrosis factor (TNF)
gene polymorphism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle schizophrenia
tumor necrosis factor (TNF)
gene polymorphism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Kadasah S
Arfin M
Rizvi S
Al-Asmari M
Al-Asmari A
Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia
description Saeed Kadasah,1 Misbahul Arfin,2 Sadaf Rizvi,2 Mohammed Al-Asmari,2 Abdulrahman Al-Asmari2 1Department of Psychiatry, 2Division of Molecular Biology & Genetics, Scientific Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia Background: Schizophrenia is one of the most common devastating psychiatric disorders that negatively affects the quality of life and psychosocial functions. Its etiology involves the interplay of complex polygenic influences and environmental risk factors. Inflammatory markers are well-known etiological factors for psychiatric disorders, including schizophrenia. Objective: The aim of this study was to investigate the association of proinflammatory cytokine genes, tumor necrosis factor (TNF)-α (-308G/A) and TNF-β (+252A/G) polymorphisms with schizophrenia susceptibility. Subjects and methods: TNF-α and TNF-β genes were amplified using amplification refractory mutation system primers in 180 schizophrenia patients and 200 healthy matched controls recruited from the Psychiatry Clinic of Prince Sultan Military Medical City, Riyadh. The frequencies of alleles and genotypes of TNF-α (-308G/A) and TNF-β (+252A/G) polymorphisms in patients were compared with those in controls. Results: The frequencies of TNF-α (-308) allele A and genotype GA were significantly higher, while those of allele G and genotype GG were lower in schizophrenia patients as compared to controls, indicating that genotype GA and allele A of TNF-α (-308G/A) may increase susceptibility to schizophrenia, while genotype GG and allele G may reduce it. On the other hand, the distribution of alleles and genotypes of TNF-β (+252A/G) polymorphism does not differ significantly in patients from controls; however, the frequency of genotype GG of TNF-β (+252A/G) was significantly higher in male patients than in female patients. The distribution of TNF-α (-308G/A) and TNF-β (+252A/G) polymorphisms was almost similar in schizophrenia patients with negative or positive symptoms. Conclusion: TNF-α (-308G/A) and TNF-β (+252G/A) polymorphisms may increase the susceptibility to schizophrenia in Saudi patients and could be a potential risk factor for its etiopathogenesis. However, further studies are warranted involving a larger sample size to strengthen our findings. Keywords: schizophrenia, tumor necrosis factor, gene polymorphism, genetics, psychiatric disorder
format article
author Kadasah S
Arfin M
Rizvi S
Al-Asmari M
Al-Asmari A
author_facet Kadasah S
Arfin M
Rizvi S
Al-Asmari M
Al-Asmari A
author_sort Kadasah S
title Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia
title_short Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia
title_full Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia
title_fullStr Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia
title_full_unstemmed Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with schizophrenia
title_sort tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in saudi patients with schizophrenia
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/6977ef8dc19e4504bce7b6ec61544128
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AT rizvis tumornecrosisfactoralphaandbetageneticpolymorphismsasariskfactorinsaudipatientswithschizophrenia
AT alasmarim tumornecrosisfactoralphaandbetageneticpolymorphismsasariskfactorinsaudipatientswithschizophrenia
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