Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease

BackgroundAlthough autonomic imbalance is associated with an increased risk for metabolic disease, its effects on nonalcoholic fatty liver disease (NAFLD) remains unclear. We aimed to evaluate whether autonomic dysfunction predicts the risk for nonalcoholic fatty liver disease (NAFLD).MethodsA total...

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Autores principales:	Inha Jung, Da Young Lee, Mi Yeon Lee, Hyemi Kwon, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Won-Young Lee, Sung-Woo Park, Se Eun Park
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	heart rate variability autonomic nervous system sympathetic nervous system parasympathetic nervous system fatty liver disease (FLD) Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/697808d9b5504b9c81b80890e2c1926d
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spelling	oai:doaj.org-article:697808d9b5504b9c81b80890e2c1926d2021-11-08T07:00:41ZAutonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease1664-239210.3389/fendo.2021.752944https://doaj.org/article/697808d9b5504b9c81b80890e2c1926d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.752944/fullhttps://doaj.org/toc/1664-2392BackgroundAlthough autonomic imbalance is associated with an increased risk for metabolic disease, its effects on nonalcoholic fatty liver disease (NAFLD) remains unclear. We aimed to evaluate whether autonomic dysfunction predicts the risk for nonalcoholic fatty liver disease (NAFLD).MethodsA total of 33,899 participants without NAFLD who underwent health screening programs between 2011 and 2018 were enrolled. NAFLD was identified by ultrasonography. Autonomic activity was estimated using heart rate variability (HRV). Time domain [standard deviation of the normal-to-normal interval (SDNN) and root mean square difference (RMSSD)]; frequency domain [total power (TP), low frequency (LF), and high frequency (HF), and LF/HF ratio were analyzed.FindingsA total 6,466 participants developed NAFLD within a median of 5.7 years. Subjects with incident NAFLD showed decreased overall autonomic modulation and vagal activity with lowered SDNN, RMSSD, HF, normalized HF, compared to those without NAFLD. As the SDNN, RMSSD, TP, LF, and HF tertiles increased, the risk of NAFLD decreased with tertile 1 being the reference group [the hazard ratios (95% confidence intervals) of tertile 3 were 0.90 (0.85–0.96), 0.83 (0.78–0.88), 0.91 (0.86-0.97), 0.93 (0.87-0.99) and 0.89 (0.83-0.94), respectively] after adjusting for potential confounders. The risk for NAFLD was significantly higher in subjects in whom sustained elevated heart rate, normalized LF, and LF/HF ratio values than in those with sustained decrease in these parameters during follow-up.ConclusionsOverall autonomic imbalance, decreased parasympathetic activity, and recently increased sympathetic activity might increase the risk of NAFLD.Inha JungDa Young LeeMi Yeon LeeHyemi KwonEun-Jung RheeCheol-Young ParkKi-Won OhWon-Young LeeSung-Woo ParkSe Eun ParkFrontiers Media S.A.articleheart rate variabilityautonomic nervous systemsympathetic nervous systemparasympathetic nervous systemfatty liver disease (FLD)Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart rate variability autonomic nervous system sympathetic nervous system parasympathetic nervous system fatty liver disease (FLD) Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	heart rate variability autonomic nervous system sympathetic nervous system parasympathetic nervous system fatty liver disease (FLD) Diseases of the endocrine glands. Clinical endocrinology RC648-665 Inha Jung Da Young Lee Mi Yeon Lee Hyemi Kwon Eun-Jung Rhee Cheol-Young Park Ki-Won Oh Won-Young Lee Sung-Woo Park Se Eun Park Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease
description	BackgroundAlthough autonomic imbalance is associated with an increased risk for metabolic disease, its effects on nonalcoholic fatty liver disease (NAFLD) remains unclear. We aimed to evaluate whether autonomic dysfunction predicts the risk for nonalcoholic fatty liver disease (NAFLD).MethodsA total of 33,899 participants without NAFLD who underwent health screening programs between 2011 and 2018 were enrolled. NAFLD was identified by ultrasonography. Autonomic activity was estimated using heart rate variability (HRV). Time domain [standard deviation of the normal-to-normal interval (SDNN) and root mean square difference (RMSSD)]; frequency domain [total power (TP), low frequency (LF), and high frequency (HF), and LF/HF ratio were analyzed.FindingsA total 6,466 participants developed NAFLD within a median of 5.7 years. Subjects with incident NAFLD showed decreased overall autonomic modulation and vagal activity with lowered SDNN, RMSSD, HF, normalized HF, compared to those without NAFLD. As the SDNN, RMSSD, TP, LF, and HF tertiles increased, the risk of NAFLD decreased with tertile 1 being the reference group [the hazard ratios (95% confidence intervals) of tertile 3 were 0.90 (0.85–0.96), 0.83 (0.78–0.88), 0.91 (0.86-0.97), 0.93 (0.87-0.99) and 0.89 (0.83-0.94), respectively] after adjusting for potential confounders. The risk for NAFLD was significantly higher in subjects in whom sustained elevated heart rate, normalized LF, and LF/HF ratio values than in those with sustained decrease in these parameters during follow-up.ConclusionsOverall autonomic imbalance, decreased parasympathetic activity, and recently increased sympathetic activity might increase the risk of NAFLD.
format	article
author	Inha Jung Da Young Lee Mi Yeon Lee Hyemi Kwon Eun-Jung Rhee Cheol-Young Park Ki-Won Oh Won-Young Lee Sung-Woo Park Se Eun Park
author_facet	Inha Jung Da Young Lee Mi Yeon Lee Hyemi Kwon Eun-Jung Rhee Cheol-Young Park Ki-Won Oh Won-Young Lee Sung-Woo Park Se Eun Park
author_sort	Inha Jung
title	Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease
title_short	Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease
title_full	Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease
title_fullStr	Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease
title_full_unstemmed	Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease
title_sort	autonomic imbalance increases the risk for non-alcoholic fatty liver disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/697808d9b5504b9c81b80890e2c1926d
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Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease

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