CD39/adenosine pathway is involved in AIDS progression.

HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associ...

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Autores principales:	Maria Nikolova, Matthieu Carriere, Mohammad-Ali Jenabian, Sophie Limou, Mehwish Younas, Ayrin Kök, Sophie Huë, Nabila Seddiki, Anne Hulin, Olivier Delaneau, Hanneke Schuitemaker, Joshua T Herbeck, James I Mullins, Maria Muhtarova, Armand Bensussan, Jean-François Zagury, Jean-Daniel Lelievre, Yves Lévy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6978a6a1af86471db9fda97b11c647d1
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spelling	oai:doaj.org-article:6978a6a1af86471db9fda97b11c647d12021-11-18T06:03:14ZCD39/adenosine pathway is involved in AIDS progression.1553-73661553-737410.1371/journal.ppat.1002110https://doaj.org/article/6978a6a1af86471db9fda97b11c647d12011-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750674/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in concert with CD73 generates adenosine. We show in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection. Treg inhibitory effects are relieved by CD39 down modulation and are reproduced by an adenosine-agonist in accordance with a higher expression of the adenosine A2A receptor on patients' T cells. Notably, the expansion of the Treg CD39+ correlates with the level of immune activation and lower CD4+ counts in HIV-1 infected patients. Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS.Maria NikolovaMatthieu CarriereMohammad-Ali JenabianSophie LimouMehwish YounasAyrin KökSophie HuëNabila SeddikiAnne HulinOlivier DelaneauHanneke SchuitemakerJoshua T HerbeckJames I MullinsMaria MuhtarovaArmand BensussanJean-François ZaguryJean-Daniel LelievreYves LévyPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 7, p e1002110 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Maria Nikolova Matthieu Carriere Mohammad-Ali Jenabian Sophie Limou Mehwish Younas Ayrin Kök Sophie Huë Nabila Seddiki Anne Hulin Olivier Delaneau Hanneke Schuitemaker Joshua T Herbeck James I Mullins Maria Muhtarova Armand Bensussan Jean-François Zagury Jean-Daniel Lelievre Yves Lévy CD39/adenosine pathway is involved in AIDS progression.
description	HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in concert with CD73 generates adenosine. We show in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection. Treg inhibitory effects are relieved by CD39 down modulation and are reproduced by an adenosine-agonist in accordance with a higher expression of the adenosine A2A receptor on patients' T cells. Notably, the expansion of the Treg CD39+ correlates with the level of immune activation and lower CD4+ counts in HIV-1 infected patients. Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS.
format	article
author	Maria Nikolova Matthieu Carriere Mohammad-Ali Jenabian Sophie Limou Mehwish Younas Ayrin Kök Sophie Huë Nabila Seddiki Anne Hulin Olivier Delaneau Hanneke Schuitemaker Joshua T Herbeck James I Mullins Maria Muhtarova Armand Bensussan Jean-François Zagury Jean-Daniel Lelievre Yves Lévy
author_facet	Maria Nikolova Matthieu Carriere Mohammad-Ali Jenabian Sophie Limou Mehwish Younas Ayrin Kök Sophie Huë Nabila Seddiki Anne Hulin Olivier Delaneau Hanneke Schuitemaker Joshua T Herbeck James I Mullins Maria Muhtarova Armand Bensussan Jean-François Zagury Jean-Daniel Lelievre Yves Lévy
author_sort	Maria Nikolova
title	CD39/adenosine pathway is involved in AIDS progression.
title_short	CD39/adenosine pathway is involved in AIDS progression.
title_full	CD39/adenosine pathway is involved in AIDS progression.
title_fullStr	CD39/adenosine pathway is involved in AIDS progression.
title_full_unstemmed	CD39/adenosine pathway is involved in AIDS progression.
title_sort	cd39/adenosine pathway is involved in aids progression.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6978a6a1af86471db9fda97b11c647d1
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CD39/adenosine pathway is involved in AIDS progression.

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