Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening

High-throughput cell-based screening of compound libraries is utilised in drug development; however, a lack of compatible methods limits direct synthesis and testing. Here, the authors present a diverse chip based synthesis system which can be combined with cell screening and demonstrate the applica...

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Autores principales:	Maximilian Benz, Mijanur R. Molla, Alexander Böser, Alisa Rosenfeld, Pavel A. Levkin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6979685daa8a4f89bb0739d8f7eb3a4f
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spelling	oai:doaj.org-article:6979685daa8a4f89bb0739d8f7eb3a4f2021-12-02T14:39:58ZMarrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening10.1038/s41467-019-10685-02041-1723https://doaj.org/article/6979685daa8a4f89bb0739d8f7eb3a4f2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10685-0https://doaj.org/toc/2041-1723High-throughput cell-based screening of compound libraries is utilised in drug development; however, a lack of compatible methods limits direct synthesis and testing. Here, the authors present a diverse chip based synthesis system which can be combined with cell screening and demonstrate the application.Maximilian BenzMijanur R. MollaAlexander BöserAlisa RosenfeldPavel A. LevkinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maximilian Benz Mijanur R. Molla Alexander Böser Alisa Rosenfeld Pavel A. Levkin Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
description	High-throughput cell-based screening of compound libraries is utilised in drug development; however, a lack of compatible methods limits direct synthesis and testing. Here, the authors present a diverse chip based synthesis system which can be combined with cell screening and demonstrate the application.
format	article
author	Maximilian Benz Mijanur R. Molla Alexander Böser Alisa Rosenfeld Pavel A. Levkin
author_facet	Maximilian Benz Mijanur R. Molla Alexander Böser Alisa Rosenfeld Pavel A. Levkin
author_sort	Maximilian Benz
title	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_short	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_full	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_fullStr	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_full_unstemmed	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_sort	marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6979685daa8a4f89bb0739d8f7eb3a4f
work_keys_str_mv	AT maximilianbenz marryingchemistrywithbiologybycombiningonchipsolutionbasedcombinatorialsynthesisandcellularscreening AT mijanurrmolla marryingchemistrywithbiologybycombiningonchipsolutionbasedcombinatorialsynthesisandcellularscreening AT alexanderboser marryingchemistrywithbiologybycombiningonchipsolutionbasedcombinatorialsynthesisandcellularscreening AT alisarosenfeld marryingchemistrywithbiologybycombiningonchipsolutionbasedcombinatorialsynthesisandcellularscreening AT pavelalevkin marryingchemistrywithbiologybycombiningonchipsolutionbasedcombinatorialsynthesisandcellularscreening
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Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening

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