Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy

Single-cell RNA-seq reveals the cellular heterogeneity in development and disease. Here the authors present a single-nucleus RNA-seq2 that allows deep characterization of nuclei isolated from frozen archived tissues, apply it for transcriptional profiling of individual hepatocytes, and determine a f...

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Autores principales:	M. L. Richter, I. K. Deligiannis, K. Yin, A. Danese, E. Lleshi, P. Coupland, C. A. Vallejos, K. P. Matchett, N. C. Henderson, M. Colome-Tatche, C. P. Martinez-Jimenez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/697a3cd8916241ab8ea28bf7c44f29bd
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spelling	oai:doaj.org-article:697a3cd8916241ab8ea28bf7c44f29bd2021-12-02T18:31:30ZSingle-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy10.1038/s41467-021-24543-52041-1723https://doaj.org/article/697a3cd8916241ab8ea28bf7c44f29bd2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24543-5https://doaj.org/toc/2041-1723Single-cell RNA-seq reveals the cellular heterogeneity in development and disease. Here the authors present a single-nucleus RNA-seq2 that allows deep characterization of nuclei isolated from frozen archived tissues, apply it for transcriptional profiling of individual hepatocytes, and determine a functional crosstalk between liver zonation and ploidy.M. L. RichterI. K. DeligiannisK. YinA. DaneseE. LleshiP. CouplandC. A. VallejosK. P. MatchettN. C. HendersonM. Colome-TatcheC. P. Martinez-JimenezNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. L. Richter I. K. Deligiannis K. Yin A. Danese E. Lleshi P. Coupland C. A. Vallejos K. P. Matchett N. C. Henderson M. Colome-Tatche C. P. Martinez-Jimenez Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
description	Single-cell RNA-seq reveals the cellular heterogeneity in development and disease. Here the authors present a single-nucleus RNA-seq2 that allows deep characterization of nuclei isolated from frozen archived tissues, apply it for transcriptional profiling of individual hepatocytes, and determine a functional crosstalk between liver zonation and ploidy.
format	article
author	M. L. Richter I. K. Deligiannis K. Yin A. Danese E. Lleshi P. Coupland C. A. Vallejos K. P. Matchett N. C. Henderson M. Colome-Tatche C. P. Martinez-Jimenez
author_facet	M. L. Richter I. K. Deligiannis K. Yin A. Danese E. Lleshi P. Coupland C. A. Vallejos K. P. Matchett N. C. Henderson M. Colome-Tatche C. P. Martinez-Jimenez
author_sort	M. L. Richter
title	Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
title_short	Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
title_full	Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
title_fullStr	Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
title_full_unstemmed	Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
title_sort	single-nucleus rna-seq2 reveals functional crosstalk between liver zonation and ploidy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/697a3cd8916241ab8ea28bf7c44f29bd
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Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy

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