VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children.
<h4>Background</h4>VNN1 gene expression levels and the G-137T polymorphism have been associated with high density lipoprotein cholesterol (HDL-C) levels in Mexican American adults. We aim to evaluate the contribution of VNN1 gene expression and the G-137T variant to HDL-C levels and othe...
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2012
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oai:doaj.org-article:697cc55149ba4bb49ae8b2995864bdd62021-11-18T08:07:53ZVNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children.1932-620310.1371/journal.pone.0049818https://doaj.org/article/697cc55149ba4bb49ae8b2995864bdd62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185446/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>VNN1 gene expression levels and the G-137T polymorphism have been associated with high density lipoprotein cholesterol (HDL-C) levels in Mexican American adults. We aim to evaluate the contribution of VNN1 gene expression and the G-137T variant to HDL-C levels and other metabolic traits in Mexican prepubertal children.<h4>Methodology/principal findings</h4>VNN1 mRNA expression levels were quantified in peripheral blood leukocytes from 224 unrelated Mexican-Mestizo children aged 6-8 years (107 boys and 117 girls) and were genotyped for the G-137T variant (rs4897612). To account for population stratification, a panel of 10 ancestry informative markers was analyzed. After adjustment for admixture, the TT genotype was significantly associated with lower VNN1 mRNA expression levels (P = 2.9 × 10(-5)), decreased HDL-C levels (β = -6.19, P = 0.028) and with higher body mass index (BMI) z-score (β = 0.48, P = 0.024) in the total sample. In addition, VNN1 expression showed a positive correlation with HDL-C levels (r = 0.220; P = 0.017) and a negative correlation with BMI z-score (r = -0.225; P = 0.015) only in girls.<h4>Conclusion/significance</h4>Our data suggest that VNN1 gene expression and the G-137T variant are associated with HDL-C levels in Mexican children, particularly in prepubertal girls.Leonor Jacobo-AlbaveraPablo I Aguayo-de la RosaTeresa Villarreal-MolinaHugo Villamil-RamírezPaola León-MimilaSandra Romero-HidalgoBlanca E López-ContrerasFausto Sánchez-MuñozRafael BojalilJuan Antonio González-BarriosCarlos A Aguilar-SalinasSamuel Canizales-QuinterosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49818 (2012) |
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Medicine R Science Q |
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Medicine R Science Q Leonor Jacobo-Albavera Pablo I Aguayo-de la Rosa Teresa Villarreal-Molina Hugo Villamil-Ramírez Paola León-Mimila Sandra Romero-Hidalgo Blanca E López-Contreras Fausto Sánchez-Muñoz Rafael Bojalil Juan Antonio González-Barrios Carlos A Aguilar-Salinas Samuel Canizales-Quinteros VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. |
| description |
<h4>Background</h4>VNN1 gene expression levels and the G-137T polymorphism have been associated with high density lipoprotein cholesterol (HDL-C) levels in Mexican American adults. We aim to evaluate the contribution of VNN1 gene expression and the G-137T variant to HDL-C levels and other metabolic traits in Mexican prepubertal children.<h4>Methodology/principal findings</h4>VNN1 mRNA expression levels were quantified in peripheral blood leukocytes from 224 unrelated Mexican-Mestizo children aged 6-8 years (107 boys and 117 girls) and were genotyped for the G-137T variant (rs4897612). To account for population stratification, a panel of 10 ancestry informative markers was analyzed. After adjustment for admixture, the TT genotype was significantly associated with lower VNN1 mRNA expression levels (P = 2.9 × 10(-5)), decreased HDL-C levels (β = -6.19, P = 0.028) and with higher body mass index (BMI) z-score (β = 0.48, P = 0.024) in the total sample. In addition, VNN1 expression showed a positive correlation with HDL-C levels (r = 0.220; P = 0.017) and a negative correlation with BMI z-score (r = -0.225; P = 0.015) only in girls.<h4>Conclusion/significance</h4>Our data suggest that VNN1 gene expression and the G-137T variant are associated with HDL-C levels in Mexican children, particularly in prepubertal girls. |
| format |
article |
| author |
Leonor Jacobo-Albavera Pablo I Aguayo-de la Rosa Teresa Villarreal-Molina Hugo Villamil-Ramírez Paola León-Mimila Sandra Romero-Hidalgo Blanca E López-Contreras Fausto Sánchez-Muñoz Rafael Bojalil Juan Antonio González-Barrios Carlos A Aguilar-Salinas Samuel Canizales-Quinteros |
| author_facet |
Leonor Jacobo-Albavera Pablo I Aguayo-de la Rosa Teresa Villarreal-Molina Hugo Villamil-Ramírez Paola León-Mimila Sandra Romero-Hidalgo Blanca E López-Contreras Fausto Sánchez-Muñoz Rafael Bojalil Juan Antonio González-Barrios Carlos A Aguilar-Salinas Samuel Canizales-Quinteros |
| author_sort |
Leonor Jacobo-Albavera |
| title |
VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. |
| title_short |
VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. |
| title_full |
VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. |
| title_fullStr |
VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. |
| title_full_unstemmed |
VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. |
| title_sort |
vnn1 gene expression levels and the g-137t polymorphism are associated with hdl-c levels in mexican prepubertal children. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/697cc55149ba4bb49ae8b2995864bdd6 |
| work_keys_str_mv |
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