Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Cerebral cavernous malformation is a vascular disease characterized by capillary-venous cavernomas in the central nervous system. Here the authors show that cavernomas display benign tumor characteristics and originate from the clonal expansion of mutated endothelial progenitors which can attract su...

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Autores principales:	Matteo Malinverno, Claudio Maderna, Abdallah Abu Taha, Monica Corada, Fabrizio Orsenigo, Mariaelena Valentino, Federica Pisati, Carmela Fusco, Paolo Graziano, Monica Giannotta, Qing Cissy Yu, Yi Arial Zeng, Maria Grazia Lampugnani, Peetra U. Magnusson, Elisabetta Dejana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/697db73cfa424b9ba46d1f4d22882162
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spelling	oai:doaj.org-article:697db73cfa424b9ba46d1f4d228821622021-12-02T15:36:20ZEndothelial cell clonal expansion in the development of cerebral cavernous malformations10.1038/s41467-019-10707-x2041-1723https://doaj.org/article/697db73cfa424b9ba46d1f4d228821622019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10707-xhttps://doaj.org/toc/2041-1723Cerebral cavernous malformation is a vascular disease characterized by capillary-venous cavernomas in the central nervous system. Here the authors show that cavernomas display benign tumor characteristics and originate from the clonal expansion of mutated endothelial progenitors which can attract surrounding wild-type cells, inducing their mesenchymal transition and leading to growth of the cavernoma.Matteo MalinvernoClaudio MadernaAbdallah Abu TahaMonica CoradaFabrizio OrsenigoMariaelena ValentinoFederica PisatiCarmela FuscoPaolo GrazianoMonica GiannottaQing Cissy YuYi Arial ZengMaria Grazia LampugnaniPeetra U. MagnussonElisabetta DejanaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo Malinverno Claudio Maderna Abdallah Abu Taha Monica Corada Fabrizio Orsenigo Mariaelena Valentino Federica Pisati Carmela Fusco Paolo Graziano Monica Giannotta Qing Cissy Yu Yi Arial Zeng Maria Grazia Lampugnani Peetra U. Magnusson Elisabetta Dejana Endothelial cell clonal expansion in the development of cerebral cavernous malformations
description	Cerebral cavernous malformation is a vascular disease characterized by capillary-venous cavernomas in the central nervous system. Here the authors show that cavernomas display benign tumor characteristics and originate from the clonal expansion of mutated endothelial progenitors which can attract surrounding wild-type cells, inducing their mesenchymal transition and leading to growth of the cavernoma.
format	article
author	Matteo Malinverno Claudio Maderna Abdallah Abu Taha Monica Corada Fabrizio Orsenigo Mariaelena Valentino Federica Pisati Carmela Fusco Paolo Graziano Monica Giannotta Qing Cissy Yu Yi Arial Zeng Maria Grazia Lampugnani Peetra U. Magnusson Elisabetta Dejana
author_facet	Matteo Malinverno Claudio Maderna Abdallah Abu Taha Monica Corada Fabrizio Orsenigo Mariaelena Valentino Federica Pisati Carmela Fusco Paolo Graziano Monica Giannotta Qing Cissy Yu Yi Arial Zeng Maria Grazia Lampugnani Peetra U. Magnusson Elisabetta Dejana
author_sort	Matteo Malinverno
title	Endothelial cell clonal expansion in the development of cerebral cavernous malformations
title_short	Endothelial cell clonal expansion in the development of cerebral cavernous malformations
title_full	Endothelial cell clonal expansion in the development of cerebral cavernous malformations
title_fullStr	Endothelial cell clonal expansion in the development of cerebral cavernous malformations
title_full_unstemmed	Endothelial cell clonal expansion in the development of cerebral cavernous malformations
title_sort	endothelial cell clonal expansion in the development of cerebral cavernous malformations
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/697db73cfa424b9ba46d1f4d22882162
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Endothelial cell clonal expansion in the development of cerebral cavernous malformations

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