Context-dependent effects of whole-genome duplication during mammary tumor recurrence

Abstract Whole-genome duplication (WGD) generates polyploid cells possessing more than two copies of the genome and is among the most common genetic abnormalities in cancer. The frequency of WGD increases in advanced and metastatic tumors, and WGD is associated with poor prognosis in diverse tumor t...

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Autores principales: Rachel Newcomb, Emily Dean, Brock J. McKinney, James V. Alvarez
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/697de7b1dc5d4dff8c6dee6e6e68404d
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