Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research

Introduction: Peripheral blood leukocytes are a suitable cell model for science research. However, blood samples from healthy volunteers are limited in volume and difficult to obtain due to the complexity of volunteer recruitment. Objective: Therefore, it is urgent to find an alternative source of p...

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Autores principales:	Shirin Ferdowsi, Zahra Abbasi-Malati, Ali Akbar Pourfathollah
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Leukocyte reduction filters Peripheral blood leukocytes Usage Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/697e9c57b39e4ad5a12684a43122303b
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spelling	oai:doaj.org-article:697e9c57b39e4ad5a12684a43122303b2021-11-04T04:37:31ZLeukocyte reduction filters as an alternative source of peripheral blood leukocytes for research2531-137910.1016/j.htct.2020.10.963https://doaj.org/article/697e9c57b39e4ad5a12684a43122303b2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137920313043https://doaj.org/toc/2531-1379Introduction: Peripheral blood leukocytes are a suitable cell model for science research. However, blood samples from healthy volunteers are limited in volume and difficult to obtain due to the complexity of volunteer recruitment. Objective: Therefore, it is urgent to find an alternative source of peripheral blood leukocytes. Method: One of the possibilities is the use of leukocyte reduction filters (LRFs) in blood banks that is used for preparation of leukoreduced blood products. More than 90% of the leukocytes are trapped in the leukofilters allowing the desired blood product to pass through. Results: It has been reported that the biological function of leukocytes collected from the filters are no different from those isolated from buffy coats, leukapheresis products and whole blood (WB) cells. Moreover, LRFs are waste products that are discarded after leukoreduction. Conclusion: Thus, leukofilters represent an economic source of human cell populations that can be used for a variety of investigative purposes, with no cost. In the present study, we reviewed the different usage of LRFs in the research, clinical and commercial applications.Shirin FerdowsiZahra Abbasi-MalatiAli Akbar PourfathollahElsevierarticleLeukocyte reduction filtersPeripheral blood leukocytesUsageDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 494-498 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Leukocyte reduction filters Peripheral blood leukocytes Usage Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Leukocyte reduction filters Peripheral blood leukocytes Usage Diseases of the blood and blood-forming organs RC633-647.5 Shirin Ferdowsi Zahra Abbasi-Malati Ali Akbar Pourfathollah Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
description	Introduction: Peripheral blood leukocytes are a suitable cell model for science research. However, blood samples from healthy volunteers are limited in volume and difficult to obtain due to the complexity of volunteer recruitment. Objective: Therefore, it is urgent to find an alternative source of peripheral blood leukocytes. Method: One of the possibilities is the use of leukocyte reduction filters (LRFs) in blood banks that is used for preparation of leukoreduced blood products. More than 90% of the leukocytes are trapped in the leukofilters allowing the desired blood product to pass through. Results: It has been reported that the biological function of leukocytes collected from the filters are no different from those isolated from buffy coats, leukapheresis products and whole blood (WB) cells. Moreover, LRFs are waste products that are discarded after leukoreduction. Conclusion: Thus, leukofilters represent an economic source of human cell populations that can be used for a variety of investigative purposes, with no cost. In the present study, we reviewed the different usage of LRFs in the research, clinical and commercial applications.
format	article
author	Shirin Ferdowsi Zahra Abbasi-Malati Ali Akbar Pourfathollah
author_facet	Shirin Ferdowsi Zahra Abbasi-Malati Ali Akbar Pourfathollah
author_sort	Shirin Ferdowsi
title	Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
title_short	Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
title_full	Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
title_fullStr	Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
title_full_unstemmed	Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
title_sort	leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/697e9c57b39e4ad5a12684a43122303b
work_keys_str_mv	AT shirinferdowsi leukocytereductionfiltersasanalternativesourceofperipheralbloodleukocytesforresearch AT zahraabbasimalati leukocytereductionfiltersasanalternativesourceofperipheralbloodleukocytesforresearch AT aliakbarpourfathollah leukocytereductionfiltersasanalternativesourceofperipheralbloodleukocytesforresearch
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Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research

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