Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients

In Japan, rebamipide (RB) mouthwash (RB-MW) for oral mucositis induced by cancer chemotherapy has been prepared using in-hospital formulation. Usually, RB-MW is prepared by dispersing crushed commercial RB tablets in the dispersion medium; however, uniformity is difficult to obtain due to low solubi...

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Autores principales:	Naoko Ishii, Senri Mizobuchi, Yayoi Kawano, Takehisa Hanawa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stomatitis chemotherapy rebamipide grinding dispersibility dispersion before use Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/69801d12422a4b58b83bcbb997a28aaf
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spelling	oai:doaj.org-article:69801d12422a4b58b83bcbb997a28aaf2021-11-25T18:41:10ZPreparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients10.3390/pharmaceutics131118481999-4923https://doaj.org/article/69801d12422a4b58b83bcbb997a28aaf2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1848https://doaj.org/toc/1999-4923In Japan, rebamipide (RB) mouthwash (RB-MW) for oral mucositis induced by cancer chemotherapy has been prepared using in-hospital formulation. Usually, RB-MW is prepared by dispersing crushed commercial RB tablets in the dispersion medium; however, uniformity is difficult to obtain due to low solubility. The current study aims is to prepare homogenously dispersed formulations using the fine particles of crushed tablets by a method that is convenient for hospital use. Commercial RB tablets were pre-milled at different milling times as “RB-Ts”. A ground mixture was then prepared by co-grinding the RB-Ts with HPC-L or PVP K30 via a benchtop ball milling machine (MM400). The physicochemical properties of samples were evaluated for PXRD, FTIR, turbidity, particle size, and solubility. Although the milling of RB tablets decreased the crystallinity, the length of milling time did not affect them. In contrast, grinding using MM400 significantly decreased RB crystallinity; their PXRD patterns showed a halo, suggesting the amorphization of RB crystals by grinding. Although solubility and turbidity seemed to be affected by the type of polymer rather than the particle size, every ground mixture showed high dispersibility. Thus, grinding the RB-Ts with polymers appeared to be the most promising way to obtain stable dispersion as an in-hospital formulation.Naoko IshiiSenri MizobuchiYayoi KawanoTakehisa HanawaMDPI AGarticlestomatitischemotherapyrebamipidegrindingdispersibilitydispersion before usePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1848, p 1848 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stomatitis chemotherapy rebamipide grinding dispersibility dispersion before use Pharmacy and materia medica RS1-441
spellingShingle	stomatitis chemotherapy rebamipide grinding dispersibility dispersion before use Pharmacy and materia medica RS1-441 Naoko Ishii Senri Mizobuchi Yayoi Kawano Takehisa Hanawa Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients
description	In Japan, rebamipide (RB) mouthwash (RB-MW) for oral mucositis induced by cancer chemotherapy has been prepared using in-hospital formulation. Usually, RB-MW is prepared by dispersing crushed commercial RB tablets in the dispersion medium; however, uniformity is difficult to obtain due to low solubility. The current study aims is to prepare homogenously dispersed formulations using the fine particles of crushed tablets by a method that is convenient for hospital use. Commercial RB tablets were pre-milled at different milling times as “RB-Ts”. A ground mixture was then prepared by co-grinding the RB-Ts with HPC-L or PVP K30 via a benchtop ball milling machine (MM400). The physicochemical properties of samples were evaluated for PXRD, FTIR, turbidity, particle size, and solubility. Although the milling of RB tablets decreased the crystallinity, the length of milling time did not affect them. In contrast, grinding using MM400 significantly decreased RB crystallinity; their PXRD patterns showed a halo, suggesting the amorphization of RB crystals by grinding. Although solubility and turbidity seemed to be affected by the type of polymer rather than the particle size, every ground mixture showed high dispersibility. Thus, grinding the RB-Ts with polymers appeared to be the most promising way to obtain stable dispersion as an in-hospital formulation.
format	article
author	Naoko Ishii Senri Mizobuchi Yayoi Kawano Takehisa Hanawa
author_facet	Naoko Ishii Senri Mizobuchi Yayoi Kawano Takehisa Hanawa
author_sort	Naoko Ishii
title	Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients
title_short	Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients
title_full	Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients
title_fullStr	Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients
title_full_unstemmed	Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients
title_sort	preparation and evaluation of a powdered rebamipide mouthwash as in-hospital formulation: considering dispersion before use in patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/69801d12422a4b58b83bcbb997a28aaf
work_keys_str_mv	AT naokoishii preparationandevaluationofapowderedrebamipidemouthwashasinhospitalformulationconsideringdispersionbeforeuseinpatients AT senrimizobuchi preparationandevaluationofapowderedrebamipidemouthwashasinhospitalformulationconsideringdispersionbeforeuseinpatients AT yayoikawano preparationandevaluationofapowderedrebamipidemouthwashasinhospitalformulationconsideringdispersionbeforeuseinpatients AT takehisahanawa preparationandevaluationofapowderedrebamipidemouthwashasinhospitalformulationconsideringdispersionbeforeuseinpatients
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Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients

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