Acne Syndromes and Mosaicism
Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chr...
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2021
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oai:doaj.org-article:6983a85c16524e1fbc9c74dd751591572021-11-25T16:51:35ZAcne Syndromes and Mosaicism10.3390/biomedicines91117352227-9059https://doaj.org/article/6983a85c16524e1fbc9c74dd751591572021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1735https://doaj.org/toc/2227-9059Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes around and in the pilosebaceous units, commonly due to hormone- and inflammatory signaling-mediated factors. Several systemic disorders, such as congenital adrenal hyperplasia, polycystic ovarian syndrome, and seborrhoea-acne-hirsutism-androgenetic alopecia syndrome have classically been associated with acne. Autoinflammatory syndromes, including PAPA, PASH, PAPASH, PsAPASH, PsaPSASH, PASS, and SAPHO syndromes include acneiform lesions as a key manifestation. Mosaic germline mutations in the <i>FGFR2</i> gene have been associated with Apert syndrome and nevus comedonicus, two illnesses that are accompanied by acneiform lesions. In this review, we summarize the concept of cutaneous mosaicism and elaborate on acne syndromes, as well as acneiform mosaicism.Sumer BaroudJim WuChristos C. ZouboulisMDPI AGarticleacnehormonessyndromesendocrinologyimmunologyautoinflammationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1735, p 1735 (2021) |
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acne hormones syndromes endocrinology immunology autoinflammation Biology (General) QH301-705.5 |
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acne hormones syndromes endocrinology immunology autoinflammation Biology (General) QH301-705.5 Sumer Baroud Jim Wu Christos C. Zouboulis Acne Syndromes and Mosaicism |
description |
Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes around and in the pilosebaceous units, commonly due to hormone- and inflammatory signaling-mediated factors. Several systemic disorders, such as congenital adrenal hyperplasia, polycystic ovarian syndrome, and seborrhoea-acne-hirsutism-androgenetic alopecia syndrome have classically been associated with acne. Autoinflammatory syndromes, including PAPA, PASH, PAPASH, PsAPASH, PsaPSASH, PASS, and SAPHO syndromes include acneiform lesions as a key manifestation. Mosaic germline mutations in the <i>FGFR2</i> gene have been associated with Apert syndrome and nevus comedonicus, two illnesses that are accompanied by acneiform lesions. In this review, we summarize the concept of cutaneous mosaicism and elaborate on acne syndromes, as well as acneiform mosaicism. |
format |
article |
author |
Sumer Baroud Jim Wu Christos C. Zouboulis |
author_facet |
Sumer Baroud Jim Wu Christos C. Zouboulis |
author_sort |
Sumer Baroud |
title |
Acne Syndromes and Mosaicism |
title_short |
Acne Syndromes and Mosaicism |
title_full |
Acne Syndromes and Mosaicism |
title_fullStr |
Acne Syndromes and Mosaicism |
title_full_unstemmed |
Acne Syndromes and Mosaicism |
title_sort |
acne syndromes and mosaicism |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/6983a85c16524e1fbc9c74dd75159157 |
work_keys_str_mv |
AT sumerbaroud acnesyndromesandmosaicism AT jimwu acnesyndromesandmosaicism AT christosczouboulis acnesyndromesandmosaicism |
_version_ |
1718412901330452480 |