Acne Syndromes and Mosaicism

Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chr...

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Autores principales: Sumer Baroud, Jim Wu, Christos C. Zouboulis
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Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/6983a85c16524e1fbc9c74dd75159157
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spelling oai:doaj.org-article:6983a85c16524e1fbc9c74dd751591572021-11-25T16:51:35ZAcne Syndromes and Mosaicism10.3390/biomedicines91117352227-9059https://doaj.org/article/6983a85c16524e1fbc9c74dd751591572021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1735https://doaj.org/toc/2227-9059Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes around and in the pilosebaceous units, commonly due to hormone- and inflammatory signaling-mediated factors. Several systemic disorders, such as congenital adrenal hyperplasia, polycystic ovarian syndrome, and seborrhoea-acne-hirsutism-androgenetic alopecia syndrome have classically been associated with acne. Autoinflammatory syndromes, including PAPA, PASH, PAPASH, PsAPASH, PsaPSASH, PASS, and SAPHO syndromes include acneiform lesions as a key manifestation. Mosaic germline mutations in the <i>FGFR2</i> gene have been associated with Apert syndrome and nevus comedonicus, two illnesses that are accompanied by acneiform lesions. In this review, we summarize the concept of cutaneous mosaicism and elaborate on acne syndromes, as well as acneiform mosaicism.Sumer BaroudJim WuChristos C. ZouboulisMDPI AGarticleacnehormonessyndromesendocrinologyimmunologyautoinflammationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1735, p 1735 (2021)
institution DOAJ
collection DOAJ
language EN
topic acne
hormones
syndromes
endocrinology
immunology
autoinflammation
Biology (General)
QH301-705.5
spellingShingle acne
hormones
syndromes
endocrinology
immunology
autoinflammation
Biology (General)
QH301-705.5
Sumer Baroud
Jim Wu
Christos C. Zouboulis
Acne Syndromes and Mosaicism
description Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes around and in the pilosebaceous units, commonly due to hormone- and inflammatory signaling-mediated factors. Several systemic disorders, such as congenital adrenal hyperplasia, polycystic ovarian syndrome, and seborrhoea-acne-hirsutism-androgenetic alopecia syndrome have classically been associated with acne. Autoinflammatory syndromes, including PAPA, PASH, PAPASH, PsAPASH, PsaPSASH, PASS, and SAPHO syndromes include acneiform lesions as a key manifestation. Mosaic germline mutations in the <i>FGFR2</i> gene have been associated with Apert syndrome and nevus comedonicus, two illnesses that are accompanied by acneiform lesions. In this review, we summarize the concept of cutaneous mosaicism and elaborate on acne syndromes, as well as acneiform mosaicism.
format article
author Sumer Baroud
Jim Wu
Christos C. Zouboulis
author_facet Sumer Baroud
Jim Wu
Christos C. Zouboulis
author_sort Sumer Baroud
title Acne Syndromes and Mosaicism
title_short Acne Syndromes and Mosaicism
title_full Acne Syndromes and Mosaicism
title_fullStr Acne Syndromes and Mosaicism
title_full_unstemmed Acne Syndromes and Mosaicism
title_sort acne syndromes and mosaicism
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/6983a85c16524e1fbc9c74dd75159157
work_keys_str_mv AT sumerbaroud acnesyndromesandmosaicism
AT jimwu acnesyndromesandmosaicism
AT christosczouboulis acnesyndromesandmosaicism
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