Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.

Berberine is one kind of isoquinoline alkaloid with anti-apoptotic effects on the neurons suffering ischemia. To address the explanation for these activities, the berberine-induced cell cycle arrest during neurons suffering ischemia/reperfusion had been studied in the present study. According to the...

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Autores principales:	Yu-Shuang Chai, Zhi-Yi Yuan, Fan Lei, Yu-Gang Wang, Jun Hu, Feng Du, Xi Lu, Jing-Fei Jiang, Dong-Ming Xing, Li-Jun Du
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69844dcde05d4912910e88c0842cd7ef
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spelling	oai:doaj.org-article:69844dcde05d4912910e88c0842cd7ef2021-11-18T08:29:18ZInhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.1932-620310.1371/journal.pone.0090850https://doaj.org/article/69844dcde05d4912910e88c0842cd7ef2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24603897/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Berberine is one kind of isoquinoline alkaloid with anti-apoptotic effects on the neurons suffering ischemia. To address the explanation for these activities, the berberine-induced cell cycle arrest during neurons suffering ischemia/reperfusion had been studied in the present study. According to the in vitro neurons with oxygen-glucose deprivation and in vivo ICR mice with cerebral ischemia/reperfusion, it was found that berberine could protect the mRNA of retinoblastoma (Rb) from degradation through its function on the poly(A) tail. The prolonged half-life of retinoblastoma 1 (gene of Rb, RB1) mRNA level secures the protein level of retinoblastoma, which facilitates cell cycle arrest of neurons in the process of ischemia/reperfusion and subsequently avoids cells entering in the apoptotic process. The poly(A) tail of RB1 mRNA, as a newly identified target of berberine, could help people focus on the interaction between berberine and mRNA to further understand the biological activities and functions of berberine.Yu-Shuang ChaiZhi-Yi YuanFan LeiYu-Gang WangJun HuFeng DuXi LuJing-Fei JiangDong-Ming XingLi-Jun DuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e90850 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Shuang Chai Zhi-Yi Yuan Fan Lei Yu-Gang Wang Jun Hu Feng Du Xi Lu Jing-Fei Jiang Dong-Ming Xing Li-Jun Du Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.
description	Berberine is one kind of isoquinoline alkaloid with anti-apoptotic effects on the neurons suffering ischemia. To address the explanation for these activities, the berberine-induced cell cycle arrest during neurons suffering ischemia/reperfusion had been studied in the present study. According to the in vitro neurons with oxygen-glucose deprivation and in vivo ICR mice with cerebral ischemia/reperfusion, it was found that berberine could protect the mRNA of retinoblastoma (Rb) from degradation through its function on the poly(A) tail. The prolonged half-life of retinoblastoma 1 (gene of Rb, RB1) mRNA level secures the protein level of retinoblastoma, which facilitates cell cycle arrest of neurons in the process of ischemia/reperfusion and subsequently avoids cells entering in the apoptotic process. The poly(A) tail of RB1 mRNA, as a newly identified target of berberine, could help people focus on the interaction between berberine and mRNA to further understand the biological activities and functions of berberine.
format	article
author	Yu-Shuang Chai Zhi-Yi Yuan Fan Lei Yu-Gang Wang Jun Hu Feng Du Xi Lu Jing-Fei Jiang Dong-Ming Xing Li-Jun Du
author_facet	Yu-Shuang Chai Zhi-Yi Yuan Fan Lei Yu-Gang Wang Jun Hu Feng Du Xi Lu Jing-Fei Jiang Dong-Ming Xing Li-Jun Du
author_sort	Yu-Shuang Chai
title	Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.
title_short	Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.
title_full	Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.
title_fullStr	Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.
title_full_unstemmed	Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.
title_sort	inhibition of retinoblastoma mrna degradation through poly (a) involved in the neuroprotective effect of berberine against cerebral ischemia.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/69844dcde05d4912910e88c0842cd7ef
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Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia.

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