8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained. The structure of the resulting adduct was confirmed...

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Autores principales:	Yuri A. Azev, Olga S. Koptyaeva, Oleg S. Eltsov, Anton N. Tsmokalyuk, Tatyana A. Pospelova
Formato:	article
Lenguaje:	EN RU
Publicado:	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2020
Materias:	5-nitro-8-hydroxyquinoline quinazoline c, c-coupling Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6986397482594e22921bdbe9e37527a5
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spelling	oai:doaj.org-article:6986397482594e22921bdbe9e37527a52021-12-01T05:53:11Z8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline2411-141410.15826/chimtech.2020.7.4.18https://doaj.org/article/6986397482594e22921bdbe9e37527a52020-12-01T00:00:00Zhttps://journals.urfu.ru/index.php/chimtech/article/view/4768https://doaj.org/toc/2411-1414The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained. The structure of the resulting adduct was confirmed by 2D 1H-13C HSQC, 1H-13C HMBC, and 1H-15N HMBC spectra.Yuri A. AzevOlga S. KoptyaevaOleg S. EltsovAnton N. TsmokalyukTatyana A. PospelovaUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina article5-nitro-8-hydroxyquinolinequinazolinec, c-couplingChemistryQD1-999ENRUChimica Techno Acta, Vol 7, Iss 4, Pp 237-241 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	5-nitro-8-hydroxyquinoline quinazoline c, c-coupling Chemistry QD1-999
spellingShingle	5-nitro-8-hydroxyquinoline quinazoline c, c-coupling Chemistry QD1-999 Yuri A. Azev Olga S. Koptyaeva Oleg S. Eltsov Anton N. Tsmokalyuk Tatyana A. Pospelova 8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline
description	The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained. The structure of the resulting adduct was confirmed by 2D 1H-13C HSQC, 1H-13C HMBC, and 1H-15N HMBC spectra.
format	article
author	Yuri A. Azev Olga S. Koptyaeva Oleg S. Eltsov Anton N. Tsmokalyuk Tatyana A. Pospelova
author_facet	Yuri A. Azev Olga S. Koptyaeva Oleg S. Eltsov Anton N. Tsmokalyuk Tatyana A. Pospelova
author_sort	Yuri A. Azev
title	8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline
title_short	8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline
title_full	8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline
title_fullStr	8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline
title_full_unstemmed	8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline
title_sort	8-hydroxy-5-nitroquinoline as a c-nucleophilic reagent in the reaction of c, c-coupling with quinazoline
publisher	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
publishDate	2020
url	https://doaj.org/article/6986397482594e22921bdbe9e37527a5
work_keys_str_mv	AT yuriaazev 8hydroxy5nitroquinolineasacnucleophilicreagentinthereactionofcccouplingwithquinazoline AT olgaskoptyaeva 8hydroxy5nitroquinolineasacnucleophilicreagentinthereactionofcccouplingwithquinazoline AT olegseltsov 8hydroxy5nitroquinolineasacnucleophilicreagentinthereactionofcccouplingwithquinazoline AT antonntsmokalyuk 8hydroxy5nitroquinolineasacnucleophilicreagentinthereactionofcccouplingwithquinazoline AT tatyanaapospelova 8hydroxy5nitroquinolineasacnucleophilicreagentinthereactionofcccouplingwithquinazoline
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8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

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