Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin

Type 2 diabetes mellitus (T2DM) is known as a complex genetic disease characterized by genetic and environmental factors. The imbalanced intestinal flora and intestinal mucosal barrier are considered to be related with T2DM. Curcumin has been proved to affect the progression of T2DM. T2DM Animal was...

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Autores principales:	Jingze Huang, Binbin Guan, Lijing Lin, Yanping Wang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	t2dm lps tlr4 curcumin Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/6986a8cc3b77483f917716d2237ff084
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spelling	oai:doaj.org-article:6986a8cc3b77483f917716d2237ff0842021-11-26T11:19:50ZImprovement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin2165-59792165-598710.1080/21655979.2021.2009322https://doaj.org/article/6986a8cc3b77483f917716d2237ff0842021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2009322https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Type 2 diabetes mellitus (T2DM) is known as a complex genetic disease characterized by genetic and environmental factors. The imbalanced intestinal flora and intestinal mucosal barrier are considered to be related with T2DM. Curcumin has been proved to affect the progression of T2DM. T2DM Animal was established by Low dose streptozotocin intraperitoneal injection combined with high-fat diet (HFD) feeding. Hematoxylin and Eosin (HE) staining and transfer electron microscopy (TEM) were used to observe morphological changes of intestinal tissues of T2DM rats. Insulin and glucose tolerance tests were performed to investigate the influence of curcumin on blood glucose. Curcumin significantly improved the intestinal integrity, hyperglycemia and insulin resistance in diabetic mice. The metabolic endotoxemia induced by HFD in diabetic rat was inhibited remarkably. Curcumin reversed gut microbiota dysbiosis in diabetic rat caused by HFD. We demonstrated that curcumin could protect intestinal mucosal barrier, improve insulin resistance and reduce blood glucose of diabetic mice. This study might provide experimental evidence for the prevention and treatment in T2DM.Jingze HuangBinbin GuanLijing LinYanping WangTaylor & Francis Grouparticlet2dmlpstlr4curcuminBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	t2dm lps tlr4 curcumin Biotechnology TP248.13-248.65
spellingShingle	t2dm lps tlr4 curcumin Biotechnology TP248.13-248.65 Jingze Huang Binbin Guan Lijing Lin Yanping Wang Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin
description	Type 2 diabetes mellitus (T2DM) is known as a complex genetic disease characterized by genetic and environmental factors. The imbalanced intestinal flora and intestinal mucosal barrier are considered to be related with T2DM. Curcumin has been proved to affect the progression of T2DM. T2DM Animal was established by Low dose streptozotocin intraperitoneal injection combined with high-fat diet (HFD) feeding. Hematoxylin and Eosin (HE) staining and transfer electron microscopy (TEM) were used to observe morphological changes of intestinal tissues of T2DM rats. Insulin and glucose tolerance tests were performed to investigate the influence of curcumin on blood glucose. Curcumin significantly improved the intestinal integrity, hyperglycemia and insulin resistance in diabetic mice. The metabolic endotoxemia induced by HFD in diabetic rat was inhibited remarkably. Curcumin reversed gut microbiota dysbiosis in diabetic rat caused by HFD. We demonstrated that curcumin could protect intestinal mucosal barrier, improve insulin resistance and reduce blood glucose of diabetic mice. This study might provide experimental evidence for the prevention and treatment in T2DM.
format	article
author	Jingze Huang Binbin Guan Lijing Lin Yanping Wang
author_facet	Jingze Huang Binbin Guan Lijing Lin Yanping Wang
author_sort	Jingze Huang
title	Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin
title_short	Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin
title_full	Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin
title_fullStr	Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin
title_full_unstemmed	Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin
title_sort	improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by curcumin
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/6986a8cc3b77483f917716d2237ff084
work_keys_str_mv	AT jingzehuang improvementofintestinalbarrierfunctiongutmicrobiotaandmetabolicendotoxemiaintype2diabetesratsbycurcumin AT binbinguan improvementofintestinalbarrierfunctiongutmicrobiotaandmetabolicendotoxemiaintype2diabetesratsbycurcumin AT lijinglin improvementofintestinalbarrierfunctiongutmicrobiotaandmetabolicendotoxemiaintype2diabetesratsbycurcumin AT yanpingwang improvementofintestinalbarrierfunctiongutmicrobiotaandmetabolicendotoxemiaintype2diabetesratsbycurcumin
_version_	1718409477183504384

Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by Curcumin

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