Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens

Although polyunsaturated fatty acids (PUFAs) have gained attention because of their physiological effects on inflammation and stress, their derivatives, termed lipid mediators, have been rarely examined, especially in laying hens. In this study, we aimed to investigate PUFA and lipid mediator profil...

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Autores principales:	Sang-Mok Lee, Hee Kyum Kim, Ho-Bin Lee, Oh-Dae Kwon, Eun-Bi Lee, Jin-Duck Bok, Chong-Su Cho, Yun-Jaie Choi, Sang-Kee Kang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	flaxseed inflammation lipid mediator omega-6 to omega-3 fatty acid balance polyunsaturated fatty acid stress Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/6987d19d2e554576af7549a873d8cb8b
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spelling	oai:doaj.org-article:6987d19d2e554576af7549a873d8cb8b2021-11-26T11:19:47ZEffects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens0971-21190974-184410.1080/09712119.2021.2000416https://doaj.org/article/6987d19d2e554576af7549a873d8cb8b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09712119.2021.2000416https://doaj.org/toc/0971-2119https://doaj.org/toc/0974-1844Although polyunsaturated fatty acids (PUFAs) have gained attention because of their physiological effects on inflammation and stress, their derivatives, termed lipid mediators, have been rarely examined, especially in laying hens. In this study, we aimed to investigate PUFA and lipid mediator profiles of laying hens after feeding 0, 0.9, 1.8, or 3.6% (w/w) dietary flaxseed (Lintex170) for 4 weeks. We also monitored the indices of inflammation (serum proinflammatory cytokines) and stress (serum corticosterone, ratio of heterophils to lymphocytes). In this study, flaxseed reduced the omega-6 to omega-3 FA ratio and increased several omega-3 FA-derived lipid mediators. Furthermore, levels of the proinflammatory cytokine tumour necrosis factor alpha and two stress indices (corticosterone, heterophil to lymphocyte ratio) were decreased when fed the 3.6% flaxseed diet. Overall, laying performance indices were also significantly improved by flaxseed treatment. These findings suggest that flaxseed may alleviate the stress state of laying hens by enriching omega-3-derived lipid mediators, which could improve laying performance.Sang-Mok LeeHee Kyum KimHo-Bin LeeOh-Dae KwonEun-Bi LeeJin-Duck BokChong-Su ChoYun-Jaie ChoiSang-Kee KangTaylor & Francis Grouparticleflaxseedinflammationlipid mediatoromega-6 to omega-3 fatty acid balancepolyunsaturated fatty acidstressVeterinary medicineSF600-1100ENJournal of Applied Animal Research, Vol 49, Iss 1, Pp 460-471 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flaxseed inflammation lipid mediator omega-6 to omega-3 fatty acid balance polyunsaturated fatty acid stress Veterinary medicine SF600-1100
spellingShingle	flaxseed inflammation lipid mediator omega-6 to omega-3 fatty acid balance polyunsaturated fatty acid stress Veterinary medicine SF600-1100 Sang-Mok Lee Hee Kyum Kim Ho-Bin Lee Oh-Dae Kwon Eun-Bi Lee Jin-Duck Bok Chong-Su Cho Yun-Jaie Choi Sang-Kee Kang Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens
description	Although polyunsaturated fatty acids (PUFAs) have gained attention because of their physiological effects on inflammation and stress, their derivatives, termed lipid mediators, have been rarely examined, especially in laying hens. In this study, we aimed to investigate PUFA and lipid mediator profiles of laying hens after feeding 0, 0.9, 1.8, or 3.6% (w/w) dietary flaxseed (Lintex170) for 4 weeks. We also monitored the indices of inflammation (serum proinflammatory cytokines) and stress (serum corticosterone, ratio of heterophils to lymphocytes). In this study, flaxseed reduced the omega-6 to omega-3 FA ratio and increased several omega-3 FA-derived lipid mediators. Furthermore, levels of the proinflammatory cytokine tumour necrosis factor alpha and two stress indices (corticosterone, heterophil to lymphocyte ratio) were decreased when fed the 3.6% flaxseed diet. Overall, laying performance indices were also significantly improved by flaxseed treatment. These findings suggest that flaxseed may alleviate the stress state of laying hens by enriching omega-3-derived lipid mediators, which could improve laying performance.
format	article
author	Sang-Mok Lee Hee Kyum Kim Ho-Bin Lee Oh-Dae Kwon Eun-Bi Lee Jin-Duck Bok Chong-Su Cho Yun-Jaie Choi Sang-Kee Kang
author_facet	Sang-Mok Lee Hee Kyum Kim Ho-Bin Lee Oh-Dae Kwon Eun-Bi Lee Jin-Duck Bok Chong-Su Cho Yun-Jaie Choi Sang-Kee Kang
author_sort	Sang-Mok Lee
title	Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens
title_short	Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens
title_full	Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens
title_fullStr	Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens
title_full_unstemmed	Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens
title_sort	effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/6987d19d2e554576af7549a873d8cb8b
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Effects of flaxseed supplementation on omega-6 to omega-3 fatty acid ratio, lipid mediator profile, proinflammatory cytokines and stress indices in laying hens

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