Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology

<i>Streptococcus suis</i> is a swine pathogen and zoonotic agent responsible for economic losses to the porcine industry. Infected animals may develop meningitis, arthritis, endocarditis, sepsis and/or sudden death. The pathogenesis of the infection implies that bacteria breach mucosal h...

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Autores principales:	Marêva Bleuzé, Marcelo Gottschalk, Mariela Segura
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Streptococcus suis</i> neutrophils innate immunity virulence factors Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/698c32e31e0c4dc3877198624c21a500
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spelling	oai:doaj.org-article:698c32e31e0c4dc3877198624c21a5002021-11-25T18:25:38ZNeutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology10.3390/microorganisms91123922076-2607https://doaj.org/article/698c32e31e0c4dc3877198624c21a5002021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2392https://doaj.org/toc/2076-2607<i>Streptococcus suis</i> is a swine pathogen and zoonotic agent responsible for economic losses to the porcine industry. Infected animals may develop meningitis, arthritis, endocarditis, sepsis and/or sudden death. The pathogenesis of the infection implies that bacteria breach mucosal host barriers and reach the bloodstream, where they escape immune-surveillance mechanisms and spread throughout the organism. The clinical manifestations are mainly the consequence of an exacerbated inflammation, defined by an exaggerated production of cytokines and recruitment of immune cells. Among them, neutrophils arrive first in contact with the pathogens to combat the infection. Neutrophils initiate and maintain inflammation, by producing cytokines and deploying their arsenal of antimicrobial mechanisms. Furthermore, neutrophilic leukocytosis characterizes <i>S. suis</i> infection, and lesions of infected subjects contain a large number of neutrophils. Therefore, this cell type may play a role in host defense and/or in the exacerbated inflammation. Nevertheless, a limited number of studies addressed the role or functions of neutrophils in the context of <i>S. suis</i> infection. In this review, we will explore the literature about <i>S. suis</i> and neutrophils, from their interaction at a cellular level, to the roles and behaviors of neutrophils in the infected host in vivo.Marêva BleuzéMarcelo GottschalkMariela SeguraMDPI AGarticle<i>Streptococcus suis</i>neutrophilsinnate immunityvirulence factorsBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2392, p 2392 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Streptococcus suis</i> neutrophils innate immunity virulence factors Biology (General) QH301-705.5
spellingShingle	<i>Streptococcus suis</i> neutrophils innate immunity virulence factors Biology (General) QH301-705.5 Marêva Bleuzé Marcelo Gottschalk Mariela Segura Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology
description	<i>Streptococcus suis</i> is a swine pathogen and zoonotic agent responsible for economic losses to the porcine industry. Infected animals may develop meningitis, arthritis, endocarditis, sepsis and/or sudden death. The pathogenesis of the infection implies that bacteria breach mucosal host barriers and reach the bloodstream, where they escape immune-surveillance mechanisms and spread throughout the organism. The clinical manifestations are mainly the consequence of an exacerbated inflammation, defined by an exaggerated production of cytokines and recruitment of immune cells. Among them, neutrophils arrive first in contact with the pathogens to combat the infection. Neutrophils initiate and maintain inflammation, by producing cytokines and deploying their arsenal of antimicrobial mechanisms. Furthermore, neutrophilic leukocytosis characterizes <i>S. suis</i> infection, and lesions of infected subjects contain a large number of neutrophils. Therefore, this cell type may play a role in host defense and/or in the exacerbated inflammation. Nevertheless, a limited number of studies addressed the role or functions of neutrophils in the context of <i>S. suis</i> infection. In this review, we will explore the literature about <i>S. suis</i> and neutrophils, from their interaction at a cellular level, to the roles and behaviors of neutrophils in the infected host in vivo.
format	article
author	Marêva Bleuzé Marcelo Gottschalk Mariela Segura
author_facet	Marêva Bleuzé Marcelo Gottschalk Mariela Segura
author_sort	Marêva Bleuzé
title	Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology
title_short	Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology
title_full	Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology
title_fullStr	Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology
title_full_unstemmed	Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology
title_sort	neutrophils in <i>streptococcus suis</i> infection: from host defense to pathology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/698c32e31e0c4dc3877198624c21a500
work_keys_str_mv	AT marevableuze neutrophilsinistreptococcussuisiinfectionfromhostdefensetopathology AT marcelogottschalk neutrophilsinistreptococcussuisiinfectionfromhostdefensetopathology AT marielasegura neutrophilsinistreptococcussuisiinfectionfromhostdefensetopathology
_version_	1718411201708294144

Neutrophils in <i>Streptococcus suis</i> Infection: From Host Defense to Pathology

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