Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.

Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued malaria transmission, has resulted more patients dealing with both communicable and non-communicable diseases. We previously reported that travelers with type 2 diabetes mellitus (T2DM) infected with Plasmodium falciparum we...

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Autores principales:	Jun-Hong Ch'ng, Kirsten Moll, Katja Wyss, Ulf Hammar, Mikael Rydén, Olle Kämpe, Anna Färnert, Mats Wahlgren
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6993028501394ce8bd54c60048d17063
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spelling	oai:doaj.org-article:6993028501394ce8bd54c60048d170632021-11-25T06:23:31ZEnhanced virulence of Plasmodium falciparum in blood of diabetic patients.1932-620310.1371/journal.pone.0249666https://doaj.org/article/6993028501394ce8bd54c60048d170632021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249666https://doaj.org/toc/1932-6203Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued malaria transmission, has resulted more patients dealing with both communicable and non-communicable diseases. We previously reported that travelers with type 2 diabetes mellitus (T2DM) infected with Plasmodium falciparum were three times more likely to develop severe malaria than non-diabetics. Here we explore the biological basis for this by testing blood from uninfected subjects with type 1 and type 2 diabetes, ex vivo, for their effects on parasite growth and rosetting (binding of infected erythrocytes to uninfected erythrocytes). Rosetting was associated with type 2 diabetes, blood glucose and erythrocyte sedimentation rate (ESR), while parasite growth was positively associated with blood glucose, glycated hemoglobin (HbA1c), body mass index (BMI), fibrinogen and triglycerides. This study establishes a link between diabetes and malaria virulence assays, potentially explaining the protective effect of good glycemic control against severe malaria in subjects with diabetes.Jun-Hong Ch'ngKirsten MollKatja WyssUlf HammarMikael RydénOlle KämpeAnna FärnertMats WahlgrenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0249666 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun-Hong Ch'ng Kirsten Moll Katja Wyss Ulf Hammar Mikael Rydén Olle Kämpe Anna Färnert Mats Wahlgren Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
description	Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued malaria transmission, has resulted more patients dealing with both communicable and non-communicable diseases. We previously reported that travelers with type 2 diabetes mellitus (T2DM) infected with Plasmodium falciparum were three times more likely to develop severe malaria than non-diabetics. Here we explore the biological basis for this by testing blood from uninfected subjects with type 1 and type 2 diabetes, ex vivo, for their effects on parasite growth and rosetting (binding of infected erythrocytes to uninfected erythrocytes). Rosetting was associated with type 2 diabetes, blood glucose and erythrocyte sedimentation rate (ESR), while parasite growth was positively associated with blood glucose, glycated hemoglobin (HbA1c), body mass index (BMI), fibrinogen and triglycerides. This study establishes a link between diabetes and malaria virulence assays, potentially explaining the protective effect of good glycemic control against severe malaria in subjects with diabetes.
format	article
author	Jun-Hong Ch'ng Kirsten Moll Katja Wyss Ulf Hammar Mikael Rydén Olle Kämpe Anna Färnert Mats Wahlgren
author_facet	Jun-Hong Ch'ng Kirsten Moll Katja Wyss Ulf Hammar Mikael Rydén Olle Kämpe Anna Färnert Mats Wahlgren
author_sort	Jun-Hong Ch'ng
title	Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
title_short	Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
title_full	Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
title_fullStr	Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
title_full_unstemmed	Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
title_sort	enhanced virulence of plasmodium falciparum in blood of diabetic patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6993028501394ce8bd54c60048d17063
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Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.

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