Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats

Abstract Spinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using spinally intact and chronic transected rats of both sexes in acute urethane-anesthetized terminal preparations, scES was systematically ap...

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Autores principales:	Robert F. Hoey, Daniel Medina-Aguiñaga, Fahmi Khalifa, Beatrice Ugiliweneza, Sharon Zdunowski, Jason Fell, Ahmed Naglah, Ayman S. El-Baz, April N. Herrity, Susan J. Harkema, Charles H. Hubscher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69935db908644956bec5213faacd046d
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spelling	oai:doaj.org-article:69935db908644956bec5213faacd046d2021-12-02T14:27:01ZBladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats10.1038/s41598-021-81822-32045-2322https://doaj.org/article/69935db908644956bec5213faacd046d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81822-3https://doaj.org/toc/2045-2322Abstract Spinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using spinally intact and chronic transected rats of both sexes in acute urethane-anesthetized terminal preparations, scES was systematically applied using a modified Specify 5–6–5 (Medtronic) electrode during bladder filling/emptying cycles while recording bladder and colorectal pressures and external urethral and anal sphincter electromyography activity. The results indicate frequency-dependent effects on void volume, micturition, bowel peristalsis, and sphincter activity just above visualized movement threshold intensities that differed depending upon neurological intactness, with some sex-dependent differences. Thereafter, a custom-designed miniature 15-electrode array designed for greater selectivity was tested and exhibited the same frequency-dependent urinary effects over a much smaller surface area without any concurrent movements. Thus, select activation of autonomic nervous system circuitries with scES is a promising neuromodulation approach for expedient translation to individuals with SCI and potentially other neurologic disorders.Robert F. HoeyDaniel Medina-AguiñagaFahmi KhalifaBeatrice UgiliwenezaSharon ZdunowskiJason FellAhmed NaglahAyman S. El-BazApril N. HerritySusan J. HarkemaCharles H. HubscherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robert F. Hoey Daniel Medina-Aguiñaga Fahmi Khalifa Beatrice Ugiliweneza Sharon Zdunowski Jason Fell Ahmed Naglah Ayman S. El-Baz April N. Herrity Susan J. Harkema Charles H. Hubscher Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats
description	Abstract Spinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using spinally intact and chronic transected rats of both sexes in acute urethane-anesthetized terminal preparations, scES was systematically applied using a modified Specify 5–6–5 (Medtronic) electrode during bladder filling/emptying cycles while recording bladder and colorectal pressures and external urethral and anal sphincter electromyography activity. The results indicate frequency-dependent effects on void volume, micturition, bowel peristalsis, and sphincter activity just above visualized movement threshold intensities that differed depending upon neurological intactness, with some sex-dependent differences. Thereafter, a custom-designed miniature 15-electrode array designed for greater selectivity was tested and exhibited the same frequency-dependent urinary effects over a much smaller surface area without any concurrent movements. Thus, select activation of autonomic nervous system circuitries with scES is a promising neuromodulation approach for expedient translation to individuals with SCI and potentially other neurologic disorders.
format	article
author	Robert F. Hoey Daniel Medina-Aguiñaga Fahmi Khalifa Beatrice Ugiliweneza Sharon Zdunowski Jason Fell Ahmed Naglah Ayman S. El-Baz April N. Herrity Susan J. Harkema Charles H. Hubscher
author_facet	Robert F. Hoey Daniel Medina-Aguiñaga Fahmi Khalifa Beatrice Ugiliweneza Sharon Zdunowski Jason Fell Ahmed Naglah Ayman S. El-Baz April N. Herrity Susan J. Harkema Charles H. Hubscher
author_sort	Robert F. Hoey
title	Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats
title_short	Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats
title_full	Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats
title_fullStr	Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats
title_full_unstemmed	Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats
title_sort	bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69935db908644956bec5213faacd046d
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Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats

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