Mapping the structural core of human cerebral cortex.

Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human...

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Autores principales:	Patric Hagmann, Leila Cammoun, Xavier Gigandet, Reto Meuli, Christopher J Honey, Van J Wedeen, Olaf Sporns
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/699440b8924f48e984214a6abf9d462a
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id	oai:doaj.org-article:699440b8924f48e984214a6abf9d462a
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spelling	oai:doaj.org-article:699440b8924f48e984214a6abf9d462a2021-11-25T05:33:18ZMapping the structural core of human cerebral cortex.1544-91731545-788510.1371/journal.pbio.0060159https://doaj.org/article/699440b8924f48e984214a6abf9d462a2008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18597554/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human participants. An analysis of the resulting large-scale structural brain networks reveals a structural core within posterior medial and parietal cerebral cortex, as well as several distinct temporal and frontal modules. Brain regions within the structural core share high degree, strength, and betweenness centrality, and they constitute connector hubs that link all major structural modules. The structural core contains brain regions that form the posterior components of the human default network. Looking both within and outside of core regions, we observed a substantial correspondence between structural connectivity and resting-state functional connectivity measured in the same participants. The spatial and topological centrality of the core within cortex suggests an important role in functional integration.Patric HagmannLeila CammounXavier GigandetReto MeuliChristopher J HoneyVan J WedeenOlaf SpornsPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 7, p e159 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Patric Hagmann Leila Cammoun Xavier Gigandet Reto Meuli Christopher J Honey Van J Wedeen Olaf Sporns Mapping the structural core of human cerebral cortex.
description	Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human participants. An analysis of the resulting large-scale structural brain networks reveals a structural core within posterior medial and parietal cerebral cortex, as well as several distinct temporal and frontal modules. Brain regions within the structural core share high degree, strength, and betweenness centrality, and they constitute connector hubs that link all major structural modules. The structural core contains brain regions that form the posterior components of the human default network. Looking both within and outside of core regions, we observed a substantial correspondence between structural connectivity and resting-state functional connectivity measured in the same participants. The spatial and topological centrality of the core within cortex suggests an important role in functional integration.
format	article
author	Patric Hagmann Leila Cammoun Xavier Gigandet Reto Meuli Christopher J Honey Van J Wedeen Olaf Sporns
author_facet	Patric Hagmann Leila Cammoun Xavier Gigandet Reto Meuli Christopher J Honey Van J Wedeen Olaf Sporns
author_sort	Patric Hagmann
title	Mapping the structural core of human cerebral cortex.
title_short	Mapping the structural core of human cerebral cortex.
title_full	Mapping the structural core of human cerebral cortex.
title_fullStr	Mapping the structural core of human cerebral cortex.
title_full_unstemmed	Mapping the structural core of human cerebral cortex.
title_sort	mapping the structural core of human cerebral cortex.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/699440b8924f48e984214a6abf9d462a
work_keys_str_mv	AT patrichagmann mappingthestructuralcoreofhumancerebralcortex AT leilacammoun mappingthestructuralcoreofhumancerebralcortex AT xaviergigandet mappingthestructuralcoreofhumancerebralcortex AT retomeuli mappingthestructuralcoreofhumancerebralcortex AT christopherjhoney mappingthestructuralcoreofhumancerebralcortex AT vanjwedeen mappingthestructuralcoreofhumancerebralcortex AT olafsporns mappingthestructuralcoreofhumancerebralcortex
_version_	1718414641733828608

Mapping the structural core of human cerebral cortex.

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