Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective

Li Zhang,1 Samantha Keogh,1,2 Claire M Rickard1,2 1Centre for Health Practice Innovation, Griffith Health Institute, Griffith University, 2Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia Abstract: Intravascular catheter-related infections are still...

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Autores principales:	Zhang L, Keogh S, Rickard CM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/699678c73ae64d0c880a42cad8bffd6b
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spelling	oai:doaj.org-article:699678c73ae64d0c880a42cad8bffd6b2021-12-02T08:08:31ZReducing the risk of infection associated with vascular access devices through nanotechnology: a perspective1176-91141178-2013https://doaj.org/article/699678c73ae64d0c880a42cad8bffd6b2013-11-01T00:00:00Zhttp://www.dovepress.com/reducing-the-risk-of-infection-associated-with-vascular-access-devices-a15033https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Li Zhang,1 Samantha Keogh,1,2 Claire M Rickard1,2 1Centre for Health Practice Innovation, Griffith Health Institute, Griffith University, 2Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia Abstract: Intravascular catheter-related infections are still a major problem in health care and are associated with significant morbidity, mortality, and additional cost. The formation of microbial biofilm on catheters makes these infections particularly complicated, as microbial cells that detach from the biofilm can lead to infection, and because these microorganisms are highly resistant to many antimicrobial agents; thus, catheter removal is often required to successfully treat infection. To reduce the risks of catheter-related infections, many strategies have been applied, such as improvements in aseptic insertion and post-insertion care practices, implantation techniques, and antibiotic coated or impregnated materials. However, despite significant advances in using these methods, it has not been possible to completely eradicate biofilm infections. Currently, nanotechnology approaches seem to be among the most promising for preventing biofilm formation and resultant catheter-related bloodstream infection (especially with multi-resistant bacterial strains). In this review, current knowledge about catheter technology and design, the mechanisms of catheter-related bloodstream infection, and the insertion and care practices performed by medical staff, are discussed, along with novel, achievable approaches to infection prevention, based on nanotechnology. Keywords: catheter related infections, biofilm, nanotechnologyZhang LKeogh SRickard CMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4453-4466 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang L Keogh S Rickard CM Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
description	Li Zhang,1 Samantha Keogh,1,2 Claire M Rickard1,2 1Centre for Health Practice Innovation, Griffith Health Institute, Griffith University, 2Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia Abstract: Intravascular catheter-related infections are still a major problem in health care and are associated with significant morbidity, mortality, and additional cost. The formation of microbial biofilm on catheters makes these infections particularly complicated, as microbial cells that detach from the biofilm can lead to infection, and because these microorganisms are highly resistant to many antimicrobial agents; thus, catheter removal is often required to successfully treat infection. To reduce the risks of catheter-related infections, many strategies have been applied, such as improvements in aseptic insertion and post-insertion care practices, implantation techniques, and antibiotic coated or impregnated materials. However, despite significant advances in using these methods, it has not been possible to completely eradicate biofilm infections. Currently, nanotechnology approaches seem to be among the most promising for preventing biofilm formation and resultant catheter-related bloodstream infection (especially with multi-resistant bacterial strains). In this review, current knowledge about catheter technology and design, the mechanisms of catheter-related bloodstream infection, and the insertion and care practices performed by medical staff, are discussed, along with novel, achievable approaches to infection prevention, based on nanotechnology. Keywords: catheter related infections, biofilm, nanotechnology
format	article
author	Zhang L Keogh S Rickard CM
author_facet	Zhang L Keogh S Rickard CM
author_sort	Zhang L
title	Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
title_short	Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
title_full	Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
title_fullStr	Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
title_full_unstemmed	Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
title_sort	reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/699678c73ae64d0c880a42cad8bffd6b
work_keys_str_mv	AT zhangl reducingtheriskofinfectionassociatedwithvascularaccessdevicesthroughnanotechnologyaperspective AT keoghs reducingtheriskofinfectionassociatedwithvascularaccessdevicesthroughnanotechnologyaperspective AT rickardcm reducingtheriskofinfectionassociatedwithvascularaccessdevicesthroughnanotechnologyaperspective
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Reducing the risk of infection associated with vascular access devices through nanotechnology: a perspective

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