Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth

Entry into the cell cycle occurs only when sufficient growth has occurred. In budding yeast, the cyclin Cln3 is thought to initiate cell cycle entry by inactivating a transcriptional repressor called Whi5. Growth-dependent changes in the concentrations of Cln3 or Whi5 have been proposed to link cell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Robert A Sommer, Jerry T DeWitt, Raymond Tan, Douglas R Kellogg
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	Cln3 cell size Whi5 cell growth cell cycle SGK Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6996cf857bf7420b95677a3e3cb106c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6996cf857bf7420b95677a3e3cb106c8
record_format	dspace
spelling	oai:doaj.org-article:6996cf857bf7420b95677a3e3cb106c82021-11-15T15:13:46ZGrowth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth10.7554/eLife.643642050-084Xe64364https://doaj.org/article/6996cf857bf7420b95677a3e3cb106c82021-10-01T00:00:00Zhttps://elifesciences.org/articles/64364https://doaj.org/toc/2050-084XEntry into the cell cycle occurs only when sufficient growth has occurred. In budding yeast, the cyclin Cln3 is thought to initiate cell cycle entry by inactivating a transcriptional repressor called Whi5. Growth-dependent changes in the concentrations of Cln3 or Whi5 have been proposed to link cell cycle entry to cell growth. However, there are conflicting reports regarding the behavior and roles of Cln3 and Whi5. Here, we found no evidence that changes in the concentration of Whi5 play a major role in controlling cell cycle entry. Rather, the data suggest that cell growth triggers cell cycle entry by driving an increase in the concentration of Cln3. We further found that accumulation of Cln3 is dependent upon homologs of mammalian SGK kinases that control cell growth and size. Together, the data are consistent with models in which Cln3 is a crucial link between cell growth and the cell cycle.Robert A SommerJerry T DeWittRaymond TanDouglas R KelloggeLife Sciences Publications LtdarticleCln3cell sizeWhi5cell growthcell cycleSGKMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cln3 cell size Whi5 cell growth cell cycle SGK Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	Cln3 cell size Whi5 cell growth cell cycle SGK Medicine R Science Q Biology (General) QH301-705.5 Robert A Sommer Jerry T DeWitt Raymond Tan Douglas R Kellogg Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth
description	Entry into the cell cycle occurs only when sufficient growth has occurred. In budding yeast, the cyclin Cln3 is thought to initiate cell cycle entry by inactivating a transcriptional repressor called Whi5. Growth-dependent changes in the concentrations of Cln3 or Whi5 have been proposed to link cell cycle entry to cell growth. However, there are conflicting reports regarding the behavior and roles of Cln3 and Whi5. Here, we found no evidence that changes in the concentration of Whi5 play a major role in controlling cell cycle entry. Rather, the data suggest that cell growth triggers cell cycle entry by driving an increase in the concentration of Cln3. We further found that accumulation of Cln3 is dependent upon homologs of mammalian SGK kinases that control cell growth and size. Together, the data are consistent with models in which Cln3 is a crucial link between cell growth and the cell cycle.
format	article
author	Robert A Sommer Jerry T DeWitt Raymond Tan Douglas R Kellogg
author_facet	Robert A Sommer Jerry T DeWitt Raymond Tan Douglas R Kellogg
author_sort	Robert A Sommer
title	Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth
title_short	Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth
title_full	Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth
title_fullStr	Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth
title_full_unstemmed	Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth
title_sort	growth-dependent signals drive an increase in early g1 cyclin concentration to link cell cycle entry with cell growth
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/6996cf857bf7420b95677a3e3cb106c8
work_keys_str_mv	AT robertasommer growthdependentsignalsdriveanincreaseinearlyg1cyclinconcentrationtolinkcellcycleentrywithcellgrowth AT jerrytdewitt growthdependentsignalsdriveanincreaseinearlyg1cyclinconcentrationtolinkcellcycleentrywithcellgrowth AT raymondtan growthdependentsignalsdriveanincreaseinearlyg1cyclinconcentrationtolinkcellcycleentrywithcellgrowth AT douglasrkellogg growthdependentsignalsdriveanincreaseinearlyg1cyclinconcentrationtolinkcellcycleentrywithcellgrowth
_version_	1718428195316826112

Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth

Ejemplares similares