Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer

Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer

Irreversible electroporation (IRE) has been approved as ablation therapy for pancreatic ductal adenocarcinoma (PDAC). Here, the authors show that, in mouse models, IRE reverses the immunosuppressive microenvironment of PDAC resulting in increased and durable response when combined with PD1 checkpoin...

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Autores principales: Jun Zhao, Xiaofei Wen, Li Tian, Tingting Li, Chunyu Xu, Xiaoxia Wen, Marites P. Melancon, Sanjay Gupta, Baozhong Shen, Weiyi Peng, Chun Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/6997acb67b654db0a21d5b14ff520bda
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spelling oai:doaj.org-article:6997acb67b654db0a21d5b14ff520bda2021-12-02T16:50:58ZIrreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer10.1038/s41467-019-08782-12041-1723https://doaj.org/article/6997acb67b654db0a21d5b14ff520bda2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08782-1https://doaj.org/toc/2041-1723Irreversible electroporation (IRE) has been approved as ablation therapy for pancreatic ductal adenocarcinoma (PDAC). Here, the authors show that, in mouse models, IRE reverses the immunosuppressive microenvironment of PDAC resulting in increased and durable response when combined with PD1 checkpoint inhibition therapy.Jun ZhaoXiaofei WenLi TianTingting LiChunyu XuXiaoxia WenMarites P. MelanconSanjay GuptaBaozhong ShenWeiyi PengChun LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Zhao
Xiaofei Wen
Li Tian
Tingting Li
Chunyu Xu
Xiaoxia Wen
Marites P. Melancon
Sanjay Gupta
Baozhong Shen
Weiyi Peng
Chun Li
Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
description Irreversible electroporation (IRE) has been approved as ablation therapy for pancreatic ductal adenocarcinoma (PDAC). Here, the authors show that, in mouse models, IRE reverses the immunosuppressive microenvironment of PDAC resulting in increased and durable response when combined with PD1 checkpoint inhibition therapy.
format article
author Jun Zhao
Xiaofei Wen
Li Tian
Tingting Li
Chunyu Xu
Xiaoxia Wen
Marites P. Melancon
Sanjay Gupta
Baozhong Shen
Weiyi Peng
Chun Li
author_facet Jun Zhao
Xiaofei Wen
Li Tian
Tingting Li
Chunyu Xu
Xiaoxia Wen
Marites P. Melancon
Sanjay Gupta
Baozhong Shen
Weiyi Peng
Chun Li
author_sort Jun Zhao
title Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
title_short Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
title_full Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
title_fullStr Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
title_full_unstemmed Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
title_sort irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/6997acb67b654db0a21d5b14ff520bda
work_keys_str_mv AT junzhao irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT xiaofeiwen irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT litian irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT tingtingli irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT chunyuxu irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT xiaoxiawen irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT maritespmelancon irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT sanjaygupta irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT baozhongshen irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT weiyipeng irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
AT chunli irreversibleelectroporationreversesresistancetoimmunecheckpointblockadeinpancreaticcancer
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