Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer

Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer

Irreversible electroporation (IRE) has been approved as ablation therapy for pancreatic ductal adenocarcinoma (PDAC). Here, the authors show that, in mouse models, IRE reverses the immunosuppressive microenvironment of PDAC resulting in increased and durable response when combined with PD1 checkpoin...

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Autores principales: Jun Zhao, Xiaofei Wen, Li Tian, Tingting Li, Chunyu Xu, Xiaoxia Wen, Marites P. Melancon, Sanjay Gupta, Baozhong Shen, Weiyi Peng, Chun Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/6997acb67b654db0a21d5b14ff520bda
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