The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with peptidoglycan and lipopolysaccharide synthesis by phosph...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Andrea Rocker, Madeleine Peschke, Tiia Kittilä, Roman Sakson, Clara Brieke, Anton Meinhart
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/699eb30358954fe0b388e73c4a1fe340
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:699eb30358954fe0b388e73c4a1fe340
record_format dspace
spelling oai:doaj.org-article:699eb30358954fe0b388e73c4a1fe3402021-12-02T15:34:04ZThe ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis10.1038/s41467-018-03652-82041-1723https://doaj.org/article/699eb30358954fe0b388e73c4a1fe3402018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03652-8https://doaj.org/toc/2041-1723Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with peptidoglycan and lipopolysaccharide synthesis by phosphorylating the UDP-activated sugar-precursors.Andrea RockerMadeleine PeschkeTiia KittiläRoman SaksonClara BriekeAnton MeinhartNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andrea Rocker
Madeleine Peschke
Tiia Kittilä
Roman Sakson
Clara Brieke
Anton Meinhart
The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
description Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with peptidoglycan and lipopolysaccharide synthesis by phosphorylating the UDP-activated sugar-precursors.
format article
author Andrea Rocker
Madeleine Peschke
Tiia Kittilä
Roman Sakson
Clara Brieke
Anton Meinhart
author_facet Andrea Rocker
Madeleine Peschke
Tiia Kittilä
Roman Sakson
Clara Brieke
Anton Meinhart
author_sort Andrea Rocker
title The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
title_short The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
title_full The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
title_fullStr The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
title_full_unstemmed The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
title_sort ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/699eb30358954fe0b388e73c4a1fe340
work_keys_str_mv AT andrearocker thengz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT madeleinepeschke thengz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT tiiakittila thengz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT romansakson thengz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT clarabrieke thengz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT antonmeinhart thengz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT andrearocker ngz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT madeleinepeschke ngz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT tiiakittila ngz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT romansakson ngz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT clarabrieke ngz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
AT antonmeinhart ngz1toxinofthegonococcalepsilonzetatoxinantitoxinsystemdrainsprecursorsforcellwallsynthesis
_version_ 1718386966815309824

Ejemplares similares