$Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus$
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Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus

Abstract The first line of treatment for pemphigus is systemic corticosteroids. When steroids alone do not result in remission, additional immunosuppressants are recommended. Twenty‐two patients with pemphigus vulugris were treated with steroids and other immunomodulators. However, they were refract...

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Autores principales:	Miwa Kanaoka, Setsuko Matsukura, Tomoko Okawa, Kazuko Nakamura, Kazuo Takahashi, Michiko Aihara
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	desmoglein methotrexate pemphigus prednisolone steroid Dermatology RL1-803 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/69a1a4a69f42451eb87a61e5f347d8a1
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spelling	oai:doaj.org-article:69a1a4a69f42451eb87a61e5f347d8a12021-11-08T15:10:52ZEfficacy of combination therapy of steroid and methotrexate for refractory pemphigus2574-459310.1002/cia2.12175https://doaj.org/article/69a1a4a69f42451eb87a61e5f347d8a12021-10-01T00:00:00Zhttps://doi.org/10.1002/cia2.12175https://doaj.org/toc/2574-4593Abstract The first line of treatment for pemphigus is systemic corticosteroids. When steroids alone do not result in remission, additional immunosuppressants are recommended. Twenty‐two patients with pemphigus vulugris were treated with steroids and other immunomodulators. However, they were refractory, and hence, methotrexate (MTX) was administered. The efficacy of MTX was assessed for 16 patients who were able to continue MTX therapy for 1 year. Steroid dose reduction was possible in 11 patients. One patient with severe infections had diabetes and was elderly. Our results suggested that MTX was useful as a steroid‐sparing agent in treating recalcitrant pemphigus, when an initial immunosuppressant treatment had failed. However, adverse effects should be closely monitored.Miwa KanaokaSetsuko MatsukuraTomoko OkawaKazuko NakamuraKazuo TakahashiMichiko AiharaWileyarticledesmogleinmethotrexatepemphigusprednisolonesteroidDermatologyRL1-803Immunologic diseases. AllergyRC581-607ENJournal of Cutaneous Immunology and Allergy, Vol 4, Iss 5, Pp 123-127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	desmoglein methotrexate pemphigus prednisolone steroid Dermatology RL1-803 Immunologic diseases. Allergy RC581-607
spellingShingle	desmoglein methotrexate pemphigus prednisolone steroid Dermatology RL1-803 Immunologic diseases. Allergy RC581-607 Miwa Kanaoka Setsuko Matsukura Tomoko Okawa Kazuko Nakamura Kazuo Takahashi Michiko Aihara Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
description	Abstract The first line of treatment for pemphigus is systemic corticosteroids. When steroids alone do not result in remission, additional immunosuppressants are recommended. Twenty‐two patients with pemphigus vulugris were treated with steroids and other immunomodulators. However, they were refractory, and hence, methotrexate (MTX) was administered. The efficacy of MTX was assessed for 16 patients who were able to continue MTX therapy for 1 year. Steroid dose reduction was possible in 11 patients. One patient with severe infections had diabetes and was elderly. Our results suggested that MTX was useful as a steroid‐sparing agent in treating recalcitrant pemphigus, when an initial immunosuppressant treatment had failed. However, adverse effects should be closely monitored.
format	article
author	Miwa Kanaoka Setsuko Matsukura Tomoko Okawa Kazuko Nakamura Kazuo Takahashi Michiko Aihara
author_facet	Miwa Kanaoka Setsuko Matsukura Tomoko Okawa Kazuko Nakamura Kazuo Takahashi Michiko Aihara
author_sort	Miwa Kanaoka
title	Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
title_short	Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
title_full	Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
title_fullStr	Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
title_full_unstemmed	Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
title_sort	efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/69a1a4a69f42451eb87a61e5f347d8a1
work_keys_str_mv	AT miwakanaoka efficacyofcombinationtherapyofsteroidandmethotrexateforrefractorypemphigus AT setsukomatsukura efficacyofcombinationtherapyofsteroidandmethotrexateforrefractorypemphigus AT tomokookawa efficacyofcombinationtherapyofsteroidandmethotrexateforrefractorypemphigus AT kazukonakamura efficacyofcombinationtherapyofsteroidandmethotrexateforrefractorypemphigus AT kazuotakahashi efficacyofcombinationtherapyofsteroidandmethotrexateforrefractorypemphigus AT michikoaihara efficacyofcombinationtherapyofsteroidandmethotrexateforrefractorypemphigus
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Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus

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