The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis

Increased urine albumin concentration (UALB) or urine albumin-to-creatinine ratio (UACR) at admission has been associated with systemic disease and increased morbidity and mortality in critically ill canine patients. The objective of this study was to assess the prognostic value of UALB and UACR for...

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Autores principales:	Oikonomidis Ioannis L., Soubasis Nectarios, Ceron Jose Joaquin, Theodorou Konstantina, Rallis Timoleon, Polizopoulou Zoe
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	dog inflammation sirs systemic inflammatory response syndrome urine albumin urine creatinine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/69a2443ca08347dba6615a3ecb549c99
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spelling	oai:doaj.org-article:69a2443ca08347dba6615a3ecb549c992021-11-17T21:27:53ZThe prognostic value of microalbuminuria in puppies with canine parvoviral enteritis1820-744810.2478/acve-2019-0008https://doaj.org/article/69a2443ca08347dba6615a3ecb549c992019-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2019-0008https://doaj.org/toc/1820-7448Increased urine albumin concentration (UALB) or urine albumin-to-creatinine ratio (UACR) at admission has been associated with systemic disease and increased morbidity and mortality in critically ill canine patients. The objective of this study was to assess the prognostic value of UALB and UACR for the survival, as well as for the development and duration of systemic inflammatory response syndrome (SIRS) in puppies with canine parvoviral enteritis (CPVE). Unvaccinated puppies, aged 1-12 months with confirmed CPVE, hospitalized for ≥5 days were included. Urine was collected at admission via cystocentesis; albumin was measured immunoturbidimetrically and creatinine spectrophotometrically. The presence of SIRS was daily evaluated. Statistical analysis was conducted using R language. Twenty-six dogs were enrolled; 12/26 (46%) developed SIRS during hospitalization, while 5/26 (19%) died. A significant correlation was found between UALB and UACR (ϱ=0.868, p<0.001). The dogs with SIRS had higher median UALB [0.5 (0-12.7) mg/dL] and UACR [4.2 (0-2,093) mg/g] compared to dogs without SIRS [UALB= 0.1 (0-0.8) mg/dL, UACR= 1.6 (0-5.6) mg/g], but the differences were non-significant (p>0.05). SIRS duration was significantly correlated with UACR (ϱ=0.427, p=0.030), but not with UALB (ϱ=0.386, p=0.052). The non-survivors had higher median UALB [0.6 (0.1-12.7) mg/dL] and UACR [19.6 (0.7-2,093) mg/g] compared to survivors [UALB= 0.2 (0-1.5) mg/dL, UACR= 2.3 (0-16.9) mg/g], but the differences were non-significant (p>0.05). UACR appears to be a prognostic indicator of SIRS duration in puppies with CPVE. However, a large-scale study is warranted to confirm the usefulness of UALB and UACR for clinical risk assessment in puppies with CPVE.Oikonomidis Ioannis L.Soubasis NectariosCeron Jose JoaquinTheodorou KonstantinaRallis TimoleonPolizopoulou ZoeSciendoarticledoginflammationsirssystemic inflammatory response syndromeurine albuminurine creatinineVeterinary medicineSF600-1100ENActa Veterinaria, Vol 69, Iss 1, Pp 116-122 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dog inflammation sirs systemic inflammatory response syndrome urine albumin urine creatinine Veterinary medicine SF600-1100
spellingShingle	dog inflammation sirs systemic inflammatory response syndrome urine albumin urine creatinine Veterinary medicine SF600-1100 Oikonomidis Ioannis L. Soubasis Nectarios Ceron Jose Joaquin Theodorou Konstantina Rallis Timoleon Polizopoulou Zoe The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis
description	Increased urine albumin concentration (UALB) or urine albumin-to-creatinine ratio (UACR) at admission has been associated with systemic disease and increased morbidity and mortality in critically ill canine patients. The objective of this study was to assess the prognostic value of UALB and UACR for the survival, as well as for the development and duration of systemic inflammatory response syndrome (SIRS) in puppies with canine parvoviral enteritis (CPVE). Unvaccinated puppies, aged 1-12 months with confirmed CPVE, hospitalized for ≥5 days were included. Urine was collected at admission via cystocentesis; albumin was measured immunoturbidimetrically and creatinine spectrophotometrically. The presence of SIRS was daily evaluated. Statistical analysis was conducted using R language. Twenty-six dogs were enrolled; 12/26 (46%) developed SIRS during hospitalization, while 5/26 (19%) died. A significant correlation was found between UALB and UACR (ϱ=0.868, p<0.001). The dogs with SIRS had higher median UALB [0.5 (0-12.7) mg/dL] and UACR [4.2 (0-2,093) mg/g] compared to dogs without SIRS [UALB= 0.1 (0-0.8) mg/dL, UACR= 1.6 (0-5.6) mg/g], but the differences were non-significant (p>0.05). SIRS duration was significantly correlated with UACR (ϱ=0.427, p=0.030), but not with UALB (ϱ=0.386, p=0.052). The non-survivors had higher median UALB [0.6 (0.1-12.7) mg/dL] and UACR [19.6 (0.7-2,093) mg/g] compared to survivors [UALB= 0.2 (0-1.5) mg/dL, UACR= 2.3 (0-16.9) mg/g], but the differences were non-significant (p>0.05). UACR appears to be a prognostic indicator of SIRS duration in puppies with CPVE. However, a large-scale study is warranted to confirm the usefulness of UALB and UACR for clinical risk assessment in puppies with CPVE.
format	article
author	Oikonomidis Ioannis L. Soubasis Nectarios Ceron Jose Joaquin Theodorou Konstantina Rallis Timoleon Polizopoulou Zoe
author_facet	Oikonomidis Ioannis L. Soubasis Nectarios Ceron Jose Joaquin Theodorou Konstantina Rallis Timoleon Polizopoulou Zoe
author_sort	Oikonomidis Ioannis L.
title	The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis
title_short	The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis
title_full	The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis
title_fullStr	The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis
title_full_unstemmed	The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis
title_sort	prognostic value of microalbuminuria in puppies with canine parvoviral enteritis
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/69a2443ca08347dba6615a3ecb549c99
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The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis

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