Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin
Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Furtherm...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Wolters Kluwer Medknow Publications
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/69a36a08b0d84579ac6dc2dba08136aa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:69a36a08b0d84579ac6dc2dba08136aa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:69a36a08b0d84579ac6dc2dba08136aa2021-11-12T10:17:53ZDoes skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin2231-40400976-209410.4103/japtr.japtr_82_21https://doaj.org/article/69a36a08b0d84579ac6dc2dba08136aa2021-01-01T00:00:00Zhttp://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=4;spage=345;epage=355;aulast=Iyerhttps://doaj.org/toc/2231-4040https://doaj.org/toc/0976-2094Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Furthermore, penetration of therapeutic entities determines the transportation and ultimately therapeutic efficacy of topical dermal dosage forms. Apart from experimentation models, mathematical equations, in silico docking, molecular dynamics (MDs), and artificial neural network (Neural) techniques are being used to assess free energies and prediction of electrostatic attractions in order to predict the permeation phenomena of therapeutic entities. Therefore, in the present review, we have summarized the significance of kinetic equations, in silico docking, MDs, and ANN in assessing and predicting the penetration behavior of topical therapeutics through dermal dosage form. In addition, the role of chitosan biomacromolecule in modulating permeation of topical therapeutics in skin has also been illustrated using computational techniques.Akshaya IyerVaskuri G. S. Sainaga JyothiAashruti AgrawalDharmendra Kumar KhatriSaurabh SrivastavaShashi Bala SinghJitender MadanWolters Kluwer Medknow Publicationsarticleartificial neural networkchitosan biomacromolecule in silico dockingpermeationskintopical deliveryTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Advanced Pharmaceutical Technology & Research, Vol 12, Iss 4, Pp 345-355 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
artificial neural network chitosan biomacromolecule in silico docking permeation skin topical delivery Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 |
| spellingShingle |
artificial neural network chitosan biomacromolecule in silico docking permeation skin topical delivery Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Akshaya Iyer Vaskuri G. S. Sainaga Jyothi Aashruti Agrawal Dharmendra Kumar Khatri Saurabh Srivastava Shashi Bala Singh Jitender Madan Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin |
| description |
Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Furthermore, penetration of therapeutic entities determines the transportation and ultimately therapeutic efficacy of topical dermal dosage forms. Apart from experimentation models, mathematical equations, in silico docking, molecular dynamics (MDs), and artificial neural network (Neural) techniques are being used to assess free energies and prediction of electrostatic attractions in order to predict the permeation phenomena of therapeutic entities. Therefore, in the present review, we have summarized the significance of kinetic equations, in silico docking, MDs, and ANN in assessing and predicting the penetration behavior of topical therapeutics through dermal dosage form. In addition, the role of chitosan biomacromolecule in modulating permeation of topical therapeutics in skin has also been illustrated using computational techniques. |
| format |
article |
| author |
Akshaya Iyer Vaskuri G. S. Sainaga Jyothi Aashruti Agrawal Dharmendra Kumar Khatri Saurabh Srivastava Shashi Bala Singh Jitender Madan |
| author_facet |
Akshaya Iyer Vaskuri G. S. Sainaga Jyothi Aashruti Agrawal Dharmendra Kumar Khatri Saurabh Srivastava Shashi Bala Singh Jitender Madan |
| author_sort |
Akshaya Iyer |
| title |
Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin |
| title_short |
Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin |
| title_full |
Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin |
| title_fullStr |
Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin |
| title_full_unstemmed |
Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin |
| title_sort |
does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2021 |
| url |
https://doaj.org/article/69a36a08b0d84579ac6dc2dba08136aa |
| work_keys_str_mv |
AT akshayaiyer doesskinpermeationkineticsinfluenceefficacyoftopicaldermaldrugdeliverysystemassessmentpredictionutilizationandintegrationofchitosanbiomacromoleculeforaugmentingtopicaldermaldrugdeliveryinskin AT vaskurigssainagajyothi doesskinpermeationkineticsinfluenceefficacyoftopicaldermaldrugdeliverysystemassessmentpredictionutilizationandintegrationofchitosanbiomacromoleculeforaugmentingtopicaldermaldrugdeliveryinskin AT aashrutiagrawal doesskinpermeationkineticsinfluenceefficacyoftopicaldermaldrugdeliverysystemassessmentpredictionutilizationandintegrationofchitosanbiomacromoleculeforaugmentingtopicaldermaldrugdeliveryinskin AT dharmendrakumarkhatri doesskinpermeationkineticsinfluenceefficacyoftopicaldermaldrugdeliverysystemassessmentpredictionutilizationandintegrationofchitosanbiomacromoleculeforaugmentingtopicaldermaldrugdeliveryinskin AT saurabhsrivastava doesskinpermeationkineticsinfluenceefficacyoftopicaldermaldrugdeliverysystemassessmentpredictionutilizationandintegrationofchitosanbiomacromoleculeforaugmentingtopicaldermaldrugdeliveryinskin AT shashibalasingh doesskinpermeationkineticsinfluenceefficacyoftopicaldermaldrugdeliverysystemassessmentpredictionutilizationandintegrationofchitosanbiomacromoleculeforaugmentingtopicaldermaldrugdeliveryinskin AT jitendermadan doesskinpermeationkineticsinfluenceefficacyoftopicaldermaldrugdeliverysystemassessmentpredictionutilizationandintegrationofchitosanbiomacromoleculeforaugmentingtopicaldermaldrugdeliveryinskin |
| _version_ |
1718430992510746624 |