Intranasal oxytocin drives coordinated social approach

Abstract Coordinated responses to challenge are essential to survival for bonded monogamous animals and may depend on behavioral compatibility. Oxytocin (OT) context-dependently regulates social affiliation and vocal communication, but its role in pair members’ decision to jointly respond to challen...

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Autores principales:	Patrick K. Monari, Nathaniel S. Rieger, Juliette Schefelker, Catherine A. Marler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69a578b377e841e68c825a17e60de404
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spelling	oai:doaj.org-article:69a578b377e841e68c825a17e60de4042021-12-02T19:12:35ZIntranasal oxytocin drives coordinated social approach10.1038/s41598-021-97468-02045-2322https://doaj.org/article/69a578b377e841e68c825a17e60de4042021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97468-0https://doaj.org/toc/2045-2322Abstract Coordinated responses to challenge are essential to survival for bonded monogamous animals and may depend on behavioral compatibility. Oxytocin (OT) context-dependently regulates social affiliation and vocal communication, but its role in pair members’ decision to jointly respond to challenge is unclear. To test for OT effects, California mouse females received an intranasal dose of OT (IN-OT) or saline after bonding with males either matched or mismatched in their approach response to an aggressive vocal challenge. Pair mates were re-tested jointly for approach response, time spent together, and vocalizations. Females and males converged in their approach after pairing, but mismatched pairs with females given a single dose of IN-OT displayed a greater convergence that resulted from behavioral changes by both pair members. Unpaired females given IN-OT did not change their approach, indicating a social partner was necessary for effects to emerge. Moreover, IN-OT increased time spent approaching together, suggesting behavioral coordination beyond a further increase in bonding. This OT-induced increase in joint approach was associated with a decrease in the proportion of sustained vocalizations, a type of vocalization that can be associated with intra-pair conflict. Our results expand OT’s effects on behavioral coordination and underscore the importance of emergent social context.Patrick K. MonariNathaniel S. RiegerJuliette SchefelkerCatherine A. MarlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrick K. Monari Nathaniel S. Rieger Juliette Schefelker Catherine A. Marler Intranasal oxytocin drives coordinated social approach
description	Abstract Coordinated responses to challenge are essential to survival for bonded monogamous animals and may depend on behavioral compatibility. Oxytocin (OT) context-dependently regulates social affiliation and vocal communication, but its role in pair members’ decision to jointly respond to challenge is unclear. To test for OT effects, California mouse females received an intranasal dose of OT (IN-OT) or saline after bonding with males either matched or mismatched in their approach response to an aggressive vocal challenge. Pair mates were re-tested jointly for approach response, time spent together, and vocalizations. Females and males converged in their approach after pairing, but mismatched pairs with females given a single dose of IN-OT displayed a greater convergence that resulted from behavioral changes by both pair members. Unpaired females given IN-OT did not change their approach, indicating a social partner was necessary for effects to emerge. Moreover, IN-OT increased time spent approaching together, suggesting behavioral coordination beyond a further increase in bonding. This OT-induced increase in joint approach was associated with a decrease in the proportion of sustained vocalizations, a type of vocalization that can be associated with intra-pair conflict. Our results expand OT’s effects on behavioral coordination and underscore the importance of emergent social context.
format	article
author	Patrick K. Monari Nathaniel S. Rieger Juliette Schefelker Catherine A. Marler
author_facet	Patrick K. Monari Nathaniel S. Rieger Juliette Schefelker Catherine A. Marler
author_sort	Patrick K. Monari
title	Intranasal oxytocin drives coordinated social approach
title_short	Intranasal oxytocin drives coordinated social approach
title_full	Intranasal oxytocin drives coordinated social approach
title_fullStr	Intranasal oxytocin drives coordinated social approach
title_full_unstemmed	Intranasal oxytocin drives coordinated social approach
title_sort	intranasal oxytocin drives coordinated social approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69a578b377e841e68c825a17e60de404
work_keys_str_mv	AT patrickkmonari intranasaloxytocindrivescoordinatedsocialapproach AT nathanielsrieger intranasaloxytocindrivescoordinatedsocialapproach AT julietteschefelker intranasaloxytocindrivescoordinatedsocialapproach AT catherineamarler intranasaloxytocindrivescoordinatedsocialapproach
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Intranasal oxytocin drives coordinated social approach

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