Cognitive effects of testosterone and finasteride administration in older hypogonadal men

Stephen E Borst,1 Joshua F Yarrow,2 Carmen Fernandez,1 Christine F Conover,2 Fan Ye,2 John R Meuleman,1 Matthew Morrow,3 Baiming Zou,4 Jonathan J Shuster5 1Geriatric Research, Education and Clinical Center, 2Research Service, 3Pharmacy Service, Malcom Randall VA Medical Center, Gainesville Florida;...

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Autores principales:	Borst SE, Yarrow JF, Fernandez C, Conover CF, Ye F, Meuleman JR, Morrow M, Zou B, Shuster JJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	hypogonadal cognition depression testosterone Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/69a6de792e334ab580baad429105984a
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spelling	oai:doaj.org-article:69a6de792e334ab580baad429105984a2021-12-02T05:44:21ZCognitive effects of testosterone and finasteride administration in older hypogonadal men1178-1998https://doaj.org/article/69a6de792e334ab580baad429105984a2014-08-01T00:00:00Zhttps://www.dovepress.com/cognitive-effects-of-testosterone-and-finasteride-administration-in-ol-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Stephen E Borst,1 Joshua F Yarrow,2 Carmen Fernandez,1 Christine F Conover,2 Fan Ye,2 John R Meuleman,1 Matthew Morrow,3 Baiming Zou,4 Jonathan J Shuster5 1Geriatric Research, Education and Clinical Center, 2Research Service, 3Pharmacy Service, Malcom Randall VA Medical Center, Gainesville Florida; 4Department of Biostatistics, 5Department of Health Outcomes and Policy, University of Florida, Gainesville, FL, USA Abstract: Serum concentrations of neuroactive androgens decline in older men and, in some studies, low testosterone is associated with decreased cognitive function and incidence of depression. Existing studies evaluating the effect of testosterone administration on cognition in older men have been largely inconclusive, with some studies reporting minor to moderate cognitive benefit, while others indicate no cognitive effect. Our objective was to assess the cognitive effects of treating older hypogonadal men for 1 year with a supraphysiological dose of testosterone, either alone or in combination with finasteride (a type II 5α-reductase inhibitor), in order to determine whether testosterone produces cognitive benefit and whether suppressed dihydrotestosterone influences cognition. Sixty men aged ≥60 years with a serum testosterone concentration of ≤300 ng/dL or bioavailable testosterone ≤70 ng/dL and no evidence of cognitive impairment received testosterone-enanthate (125 mg/week) versus vehicle, paired with finasteride (5 mg/day) versus placebo using a 2×2 factorial design. Testosterone caused a small decrease in depressive symptoms as assessed by the Geriatric Depression Scale and a moderate increase in visuospatial memory as assessed by performance on a recall trial of the Rey-Osterrieth Complex Figure Test. Finasteride caused a small increase in performance on the Benton Judgment of Line Orientation test. In total, major improvements in cognition were not observed either with testosterone or finasteride. Further studies are warranted to determine if testosterone replacement may improve cognition in other domains. Keywords: cognition, depression, 5 alpha reductase, testosterone enanthateBorst SEYarrow JFFernandez CConover CFYe FMeuleman JRMorrow MZou BShuster JJDove Medical PressarticlehypogonadalcognitiondepressiontestosteroneGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1327-1333 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypogonadal cognition depression testosterone Geriatrics RC952-954.6
spellingShingle	hypogonadal cognition depression testosterone Geriatrics RC952-954.6 Borst SE Yarrow JF Fernandez C Conover CF Ye F Meuleman JR Morrow M Zou B Shuster JJ Cognitive effects of testosterone and finasteride administration in older hypogonadal men
description	Stephen E Borst,1 Joshua F Yarrow,2 Carmen Fernandez,1 Christine F Conover,2 Fan Ye,2 John R Meuleman,1 Matthew Morrow,3 Baiming Zou,4 Jonathan J Shuster5 1Geriatric Research, Education and Clinical Center, 2Research Service, 3Pharmacy Service, Malcom Randall VA Medical Center, Gainesville Florida; 4Department of Biostatistics, 5Department of Health Outcomes and Policy, University of Florida, Gainesville, FL, USA Abstract: Serum concentrations of neuroactive androgens decline in older men and, in some studies, low testosterone is associated with decreased cognitive function and incidence of depression. Existing studies evaluating the effect of testosterone administration on cognition in older men have been largely inconclusive, with some studies reporting minor to moderate cognitive benefit, while others indicate no cognitive effect. Our objective was to assess the cognitive effects of treating older hypogonadal men for 1 year with a supraphysiological dose of testosterone, either alone or in combination with finasteride (a type II 5α-reductase inhibitor), in order to determine whether testosterone produces cognitive benefit and whether suppressed dihydrotestosterone influences cognition. Sixty men aged ≥60 years with a serum testosterone concentration of ≤300 ng/dL or bioavailable testosterone ≤70 ng/dL and no evidence of cognitive impairment received testosterone-enanthate (125 mg/week) versus vehicle, paired with finasteride (5 mg/day) versus placebo using a 2×2 factorial design. Testosterone caused a small decrease in depressive symptoms as assessed by the Geriatric Depression Scale and a moderate increase in visuospatial memory as assessed by performance on a recall trial of the Rey-Osterrieth Complex Figure Test. Finasteride caused a small increase in performance on the Benton Judgment of Line Orientation test. In total, major improvements in cognition were not observed either with testosterone or finasteride. Further studies are warranted to determine if testosterone replacement may improve cognition in other domains. Keywords: cognition, depression, 5 alpha reductase, testosterone enanthate
format	article
author	Borst SE Yarrow JF Fernandez C Conover CF Ye F Meuleman JR Morrow M Zou B Shuster JJ
author_facet	Borst SE Yarrow JF Fernandez C Conover CF Ye F Meuleman JR Morrow M Zou B Shuster JJ
author_sort	Borst SE
title	Cognitive effects of testosterone and finasteride administration in older hypogonadal men
title_short	Cognitive effects of testosterone and finasteride administration in older hypogonadal men
title_full	Cognitive effects of testosterone and finasteride administration in older hypogonadal men
title_fullStr	Cognitive effects of testosterone and finasteride administration in older hypogonadal men
title_full_unstemmed	Cognitive effects of testosterone and finasteride administration in older hypogonadal men
title_sort	cognitive effects of testosterone and finasteride administration in older hypogonadal men
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/69a6de792e334ab580baad429105984a
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Cognitive effects of testosterone and finasteride administration in older hypogonadal men

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