The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer

The human contact system consists of plasma proteins, which - after contact to foreign surfaces - are bound to them, thereby activating the zymogens of the system into enzymes. This activation mechanism gave the system its name - contact system. It is considered as a procoagulant and proinflammatory...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sonja Oehmcke-Hecht, Peggy Berlin, Brigitte Müller-Hilke, Bernd Kreikemeyer, Praveen Vasudevan, Larissa Henze, Valeria Khaimov, Brigitte Vollmar, Robert David, Claudia Maletzki
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Contact system Sepsis Arthritis Colitis Cardiovascular disease Cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/69aca1565cde4d59bfde1a3f6acdc711
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:69aca1565cde4d59bfde1a3f6acdc711
record_format	dspace
spelling	oai:doaj.org-article:69aca1565cde4d59bfde1a3f6acdc7112021-11-20T04:55:52ZThe versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer0753-332210.1016/j.biopha.2021.112429https://doaj.org/article/69aca1565cde4d59bfde1a3f6acdc7112022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012154https://doaj.org/toc/0753-3322The human contact system consists of plasma proteins, which - after contact to foreign surfaces - are bound to them, thereby activating the zymogens of the system into enzymes. This activation mechanism gave the system its name - contact system. It is considered as a procoagulant and proinflammatory response mechanism, as activation finally leads to the generation of fibrin and bradykinin. To date, no physiological processes have been described that are mediated by contact activation. However, contact system factors play a pathophysiological role in numerous diseases, such as cardiovascular diseases, arthritis, colitis, sepsis, and cancer. Contact system factors are therefore an interesting target for new therapeutic options in different clinical conditions.Sonja Oehmcke-HechtPeggy BerlinBrigitte Müller-HilkeBernd KreikemeyerPraveen VasudevanLarissa HenzeValeria KhaimovBrigitte VollmarRobert DavidClaudia MaletzkiElsevierarticleContact systemSepsisArthritisColitisCardiovascular diseaseCancerTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112429- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Contact system Sepsis Arthritis Colitis Cardiovascular disease Cancer Therapeutics. Pharmacology RM1-950
spellingShingle	Contact system Sepsis Arthritis Colitis Cardiovascular disease Cancer Therapeutics. Pharmacology RM1-950 Sonja Oehmcke-Hecht Peggy Berlin Brigitte Müller-Hilke Bernd Kreikemeyer Praveen Vasudevan Larissa Henze Valeria Khaimov Brigitte Vollmar Robert David Claudia Maletzki The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer
description	The human contact system consists of plasma proteins, which - after contact to foreign surfaces - are bound to them, thereby activating the zymogens of the system into enzymes. This activation mechanism gave the system its name - contact system. It is considered as a procoagulant and proinflammatory response mechanism, as activation finally leads to the generation of fibrin and bradykinin. To date, no physiological processes have been described that are mediated by contact activation. However, contact system factors play a pathophysiological role in numerous diseases, such as cardiovascular diseases, arthritis, colitis, sepsis, and cancer. Contact system factors are therefore an interesting target for new therapeutic options in different clinical conditions.
format	article
author	Sonja Oehmcke-Hecht Peggy Berlin Brigitte Müller-Hilke Bernd Kreikemeyer Praveen Vasudevan Larissa Henze Valeria Khaimov Brigitte Vollmar Robert David Claudia Maletzki
author_facet	Sonja Oehmcke-Hecht Peggy Berlin Brigitte Müller-Hilke Bernd Kreikemeyer Praveen Vasudevan Larissa Henze Valeria Khaimov Brigitte Vollmar Robert David Claudia Maletzki
author_sort	Sonja Oehmcke-Hecht
title	The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer
title_short	The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer
title_full	The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer
title_fullStr	The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer
title_full_unstemmed	The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer
title_sort	versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/69aca1565cde4d59bfde1a3f6acdc711
work_keys_str_mv	AT sonjaoehmckehecht theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT peggyberlin theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT brigittemullerhilke theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT berndkreikemeyer theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT praveenvasudevan theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT larissahenze theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT valeriakhaimov theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT brigittevollmar theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT robertdavid theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT claudiamaletzki theversatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT sonjaoehmckehecht versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT peggyberlin versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT brigittemullerhilke versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT berndkreikemeyer versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT praveenvasudevan versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT larissahenze versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT valeriakhaimov versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT brigittevollmar versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT robertdavid versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer AT claudiamaletzki versatileroleofthecontactsystemincardiovasculardiseaseinflammationsepsisandcancer
_version_	1718419718854934528

The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer

Ejemplares similares