Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein.

Parkinson's disease (PD) is associated with excessive cell death causing selective loss of dopaminergic neurons. Dysfunction of the Ubiquitin Proteasome System (UPS) is associated with the pathophysiology of PD. Mutations in Parkin which impair its E3-ligase activity play a major role in the pa...

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Autores principales: Stav Kemeny, Dikla Dery, Yelena Loboda, Marshall Rovner, Tali Lev, Dotan Zuri, John P M Finberg, Sarit Larisch
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/69ad29b6430a4995b84f2c17c98c66f8
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