Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

Metastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of this pathway decreases lung metastasis formation...

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Main Authors:	Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli, Martin F. Orth, Catherine Verfaillie, Thomas G. P. Grünewald, Sarah-Maria Fendt
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/69af72ab34f4448d9adc1e35ac453ca9
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id	oai:doaj.org-article:69af72ab34f4448d9adc1e35ac453ca9
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spelling	oai:doaj.org-article:69af72ab34f4448d9adc1e35ac453ca92021-12-02T14:42:18ZProline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells10.1038/ncomms152672041-1723https://doaj.org/article/69af72ab34f4448d9adc1e35ac453ca92017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15267https://doaj.org/toc/2041-1723Metastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of this pathway decreases lung metastasis formation in two mouse models.Ilaria EliaDorien BroekaertStefan ChristenRuben BoonEnrico RadaelliMartin F. OrthCatherine VerfaillieThomas G. P. GrünewaldSarah-Maria FendtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ilaria Elia Dorien Broekaert Stefan Christen Ruben Boon Enrico Radaelli Martin F. Orth Catherine Verfaillie Thomas G. P. Grünewald Sarah-Maria Fendt Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
description	Metastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of this pathway decreases lung metastasis formation in two mouse models.
format	article
author	Ilaria Elia Dorien Broekaert Stefan Christen Ruben Boon Enrico Radaelli Martin F. Orth Catherine Verfaillie Thomas G. P. Grünewald Sarah-Maria Fendt
author_facet	Ilaria Elia Dorien Broekaert Stefan Christen Ruben Boon Enrico Radaelli Martin F. Orth Catherine Verfaillie Thomas G. P. Grünewald Sarah-Maria Fendt
author_sort	Ilaria Elia
title	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_short	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_full	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_fullStr	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_full_unstemmed	Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
title_sort	proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/69af72ab34f4448d9adc1e35ac453ca9
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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

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