Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution

Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rati...

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Autores principales: Eva S. Cunha, Xiaorui Chen, Marta Sanz-Gaitero, Deryck J. Mills, Hartmut Luecke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e00
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spelling oai:doaj.org-article:69b0a175c71544c4a7319b5dccd61e002021-12-02T14:11:51ZCryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution10.1038/s41467-020-20485-62041-1723https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e002021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20485-6https://doaj.org/toc/2041-1723Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rational drug design.Eva S. CunhaXiaorui ChenMarta Sanz-GaiteroDeryck J. MillsHartmut LueckeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Eva S. Cunha
Xiaorui Chen
Marta Sanz-Gaitero
Deryck J. Mills
Hartmut Luecke
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
description Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rational drug design.
format article
author Eva S. Cunha
Xiaorui Chen
Marta Sanz-Gaitero
Deryck J. Mills
Hartmut Luecke
author_facet Eva S. Cunha
Xiaorui Chen
Marta Sanz-Gaitero
Deryck J. Mills
Hartmut Luecke
author_sort Eva S. Cunha
title Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_short Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_full Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_fullStr Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_full_unstemmed Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_sort cryo-em structure of helicobacter pylori urease with an inhibitor in the active site at 2.0 å resolution
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e00
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