Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rati...
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Nature Portfolio
2021
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oai:doaj.org-article:69b0a175c71544c4a7319b5dccd61e002021-12-02T14:11:51ZCryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution10.1038/s41467-020-20485-62041-1723https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e002021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20485-6https://doaj.org/toc/2041-1723Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rational drug design.Eva S. CunhaXiaorui ChenMarta Sanz-GaiteroDeryck J. MillsHartmut LueckeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021) |
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Science Q Eva S. Cunha Xiaorui Chen Marta Sanz-Gaitero Deryck J. Mills Hartmut Luecke Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution |
description |
Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rational drug design. |
format |
article |
author |
Eva S. Cunha Xiaorui Chen Marta Sanz-Gaitero Deryck J. Mills Hartmut Luecke |
author_facet |
Eva S. Cunha Xiaorui Chen Marta Sanz-Gaitero Deryck J. Mills Hartmut Luecke |
author_sort |
Eva S. Cunha |
title |
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution |
title_short |
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution |
title_full |
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution |
title_fullStr |
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution |
title_full_unstemmed |
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution |
title_sort |
cryo-em structure of helicobacter pylori urease with an inhibitor in the active site at 2.0 å resolution |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e00 |
work_keys_str_mv |
AT evascunha cryoemstructureofhelicobacterpyloriureasewithaninhibitorintheactivesiteat20aresolution AT xiaoruichen cryoemstructureofhelicobacterpyloriureasewithaninhibitorintheactivesiteat20aresolution AT martasanzgaitero cryoemstructureofhelicobacterpyloriureasewithaninhibitorintheactivesiteat20aresolution AT deryckjmills cryoemstructureofhelicobacterpyloriureasewithaninhibitorintheactivesiteat20aresolution AT hartmutluecke cryoemstructureofhelicobacterpyloriureasewithaninhibitorintheactivesiteat20aresolution |
_version_ |
1718391847196295168 |