Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution

Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rati...

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Auteurs principaux:	Eva S. Cunha, Xiaorui Chen, Marta Sanz-Gaitero, Deryck J. Mills, Hartmut Luecke
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e00
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spelling	oai:doaj.org-article:69b0a175c71544c4a7319b5dccd61e002021-12-02T14:11:51ZCryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution10.1038/s41467-020-20485-62041-1723https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e002021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20485-6https://doaj.org/toc/2041-1723Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rational drug design.Eva S. CunhaXiaorui ChenMarta Sanz-GaiteroDeryck J. MillsHartmut LueckeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eva S. Cunha Xiaorui Chen Marta Sanz-Gaitero Deryck J. Mills Hartmut Luecke Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
description	Infection by Helicobacter pylori is associated with peptic ulcers and gastric cancer. H. pylori urease is required for colonization of the stomach and thus an attractive antimicrobial drug target. Cryo-EM analyses of the H. pylori urease with inhibitors bound reveal structural details useful in rational drug design.
format	article
author	Eva S. Cunha Xiaorui Chen Marta Sanz-Gaitero Deryck J. Mills Hartmut Luecke
author_facet	Eva S. Cunha Xiaorui Chen Marta Sanz-Gaitero Deryck J. Mills Hartmut Luecke
author_sort	Eva S. Cunha
title	Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_short	Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_full	Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_fullStr	Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_full_unstemmed	Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution
title_sort	cryo-em structure of helicobacter pylori urease with an inhibitor in the active site at 2.0 å resolution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69b0a175c71544c4a7319b5dccd61e00
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Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution

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