Low FT3: a possible marker of frailty in the elderly

Aldo Bertoli,1 Alessia Valentini,1 Maria Assunta Cianfarani,1 Elena Gasbarra,2 Umberto Tarantino,2 Massimo Federici1 1Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Department of Orthopaedics and Traumatology, University of Rome “Tor Ve...

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Autores principales:	Bertoli A, Valentini A, Cianfarani MA, Gasbarra E, Tarantino U, Federici M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	FT3 Frailty NTIS Hip Fracture Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/69b0fc632342481687af36c4a5d446fd
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spelling	oai:doaj.org-article:69b0fc632342481687af36c4a5d446fd2021-12-02T03:03:53ZLow FT3: a possible marker of frailty in the elderly1178-1998https://doaj.org/article/69b0fc632342481687af36c4a5d446fd2017-02-01T00:00:00Zhttps://www.dovepress.com/low-ft3-a-possible--marker-of-frailty-in-the-elderly-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Aldo Bertoli,1 Alessia Valentini,1 Maria Assunta Cianfarani,1 Elena Gasbarra,2 Umberto Tarantino,2 Massimo Federici1 1Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Department of Orthopaedics and Traumatology, University of Rome “Tor Vergata”, Rome, Italy Introduction: Frailty is associated with a functional decline of multiple physiological systems, of which they may be a cause or consequence. The objective of the study was to evaluate the prevalence of thyroid hormone modifications in elderly frail subjects and its relationship with frailty.Study population and methods: An observational study was carried out at the University Hospital “Tor Vergata” in Rome among ambulatory and hospitalized patients. The study population consisted of 112 elderly subjects: 62 were hospitalized following hip fracture and 50 control subjects were outpatients. Participating patients received a multidimensional geriatric evaluation. The Survey of Health, Ageing and Retirement in Europe Frailty Instrument (SHARE-FI) was used to assess the degree of frailty. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were measured to evaluate thyroid status.Results: FT3, but not FT4, was significantly correlated with Frailty score, both in patients with hip fracture and in patients from the control group. In the entire study population, FT3 under normal limits is effective in discriminating frail/prefrail subjects from nonfrail subjects.Discussion: The reduction in serum concentrations of FT3 is a clear manifestation of stress associated with fractures. Numerous preexisting factors, such as the fracture patients’ nutritional status, sarcopenia, disability and comorbidities, which characterize the condition of frailty and influence its pathogenesis, are strongly correlated with FT3 values, suggesting the existence of latent nonthyroidal illness syndrome (NTIS).Conclusion: We conclude that measuring FT3 can be a useful laboratory parameter in clinical assessment, which can play an important role in identifying vulnerable elderly subjects and in quantifying the condition of frailty. Keywords: FT3, frailty, NTIS, hip fracture, agingBertoli AValentini ACianfarani MAGasbarra ETarantino UFederici MDove Medical PressarticleFT3FrailtyNTISHip FractureGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 335-341 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	FT3 Frailty NTIS Hip Fracture Geriatrics RC952-954.6
spellingShingle	FT3 Frailty NTIS Hip Fracture Geriatrics RC952-954.6 Bertoli A Valentini A Cianfarani MA Gasbarra E Tarantino U Federici M Low FT3: a possible marker of frailty in the elderly
description	Aldo Bertoli,1 Alessia Valentini,1 Maria Assunta Cianfarani,1 Elena Gasbarra,2 Umberto Tarantino,2 Massimo Federici1 1Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Department of Orthopaedics and Traumatology, University of Rome “Tor Vergata”, Rome, Italy Introduction: Frailty is associated with a functional decline of multiple physiological systems, of which they may be a cause or consequence. The objective of the study was to evaluate the prevalence of thyroid hormone modifications in elderly frail subjects and its relationship with frailty.Study population and methods: An observational study was carried out at the University Hospital “Tor Vergata” in Rome among ambulatory and hospitalized patients. The study population consisted of 112 elderly subjects: 62 were hospitalized following hip fracture and 50 control subjects were outpatients. Participating patients received a multidimensional geriatric evaluation. The Survey of Health, Ageing and Retirement in Europe Frailty Instrument (SHARE-FI) was used to assess the degree of frailty. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were measured to evaluate thyroid status.Results: FT3, but not FT4, was significantly correlated with Frailty score, both in patients with hip fracture and in patients from the control group. In the entire study population, FT3 under normal limits is effective in discriminating frail/prefrail subjects from nonfrail subjects.Discussion: The reduction in serum concentrations of FT3 is a clear manifestation of stress associated with fractures. Numerous preexisting factors, such as the fracture patients’ nutritional status, sarcopenia, disability and comorbidities, which characterize the condition of frailty and influence its pathogenesis, are strongly correlated with FT3 values, suggesting the existence of latent nonthyroidal illness syndrome (NTIS).Conclusion: We conclude that measuring FT3 can be a useful laboratory parameter in clinical assessment, which can play an important role in identifying vulnerable elderly subjects and in quantifying the condition of frailty. Keywords: FT3, frailty, NTIS, hip fracture, aging
format	article
author	Bertoli A Valentini A Cianfarani MA Gasbarra E Tarantino U Federici M
author_facet	Bertoli A Valentini A Cianfarani MA Gasbarra E Tarantino U Federici M
author_sort	Bertoli A
title	Low FT3: a possible marker of frailty in the elderly
title_short	Low FT3: a possible marker of frailty in the elderly
title_full	Low FT3: a possible marker of frailty in the elderly
title_fullStr	Low FT3: a possible marker of frailty in the elderly
title_full_unstemmed	Low FT3: a possible marker of frailty in the elderly
title_sort	low ft3: a possible marker of frailty in the elderly
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/69b0fc632342481687af36c4a5d446fd
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Low FT3: a possible marker of frailty in the elderly

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