A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

Human EXOG is crucial for mitochondrial DNA repair. Here the authors present the crystal structures of hEXOG in apo form and as DNA complex and suggest a `tape-measure' activity to generate optimal substrates for mitochondrial base excision repair.

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Autores principales:	Michal R. Szymanski, Wangsheng Yu, Aleksandra M. Gmyrek, Mark A. White, Ian J. Molineux, J. Ching Lee, Y. Whitney Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69b2fef277bd4fcea402f22d42c7215c
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spelling	oai:doaj.org-article:69b2fef277bd4fcea402f22d42c7215c2021-12-02T17:06:10ZA domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease10.1038/ncomms149592041-1723https://doaj.org/article/69b2fef277bd4fcea402f22d42c7215c2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms14959https://doaj.org/toc/2041-1723Human EXOG is crucial for mitochondrial DNA repair. Here the authors present the crystal structures of hEXOG in apo form and as DNA complex and suggest a `tape-measure' activity to generate optimal substrates for mitochondrial base excision repair.Michal R. SzymanskiWangsheng YuAleksandra M. GmyrekMark A. WhiteIan J. MolineuxJ. Ching LeeY. Whitney YinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal R. Szymanski Wangsheng Yu Aleksandra M. Gmyrek Mark A. White Ian J. Molineux J. Ching Lee Y. Whitney Yin A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
description	Human EXOG is crucial for mitochondrial DNA repair. Here the authors present the crystal structures of hEXOG in apo form and as DNA complex and suggest a `tape-measure' activity to generate optimal substrates for mitochondrial base excision repair.
format	article
author	Michal R. Szymanski Wangsheng Yu Aleksandra M. Gmyrek Mark A. White Ian J. Molineux J. Ching Lee Y. Whitney Yin
author_facet	Michal R. Szymanski Wangsheng Yu Aleksandra M. Gmyrek Mark A. White Ian J. Molineux J. Ching Lee Y. Whitney Yin
author_sort	Michal R. Szymanski
title	A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
title_short	A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
title_full	A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
title_fullStr	A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
title_full_unstemmed	A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
title_sort	domain in human exog converts apoptotic endonuclease to dna-repair exonuclease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/69b2fef277bd4fcea402f22d42c7215c
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A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

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