A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

Human EXOG is crucial for mitochondrial DNA repair. Here the authors present the crystal structures of hEXOG in apo form and as DNA complex and suggest a `tape-measure' activity to generate optimal substrates for mitochondrial base excision repair.

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Autores principales: Michal R. Szymanski, Wangsheng Yu, Aleksandra M. Gmyrek, Mark A. White, Ian J. Molineux, J. Ching Lee, Y. Whitney Yin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/69b2fef277bd4fcea402f22d42c7215c
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