Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.
Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- c...
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2013
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oai:doaj.org-article:69b38235dda14810abf04c5870b36bc32021-11-18T08:50:26ZAfghan Hindu Kush: where Eurasian sub-continent gene flows converge.1932-620310.1371/journal.pone.0076748https://doaj.org/article/69b38235dda14810abf04c5870b36bc32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204668/?tool=EBIhttps://doaj.org/toc/1932-6203Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci.Julie Di CristofaroErwan PennarunStéphane MazièresNatalie M MyresAlice A LinShah Aga TemoriMait MetspaluEne MetspaluMichael WitzelRoy J KingPeter A UnderhillRichard VillemsJacques ChiaroniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e76748 (2013) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Julie Di Cristofaro Erwan Pennarun Stéphane Mazières Natalie M Myres Alice A Lin Shah Aga Temori Mait Metspalu Ene Metspalu Michael Witzel Roy J King Peter A Underhill Richard Villems Jacques Chiaroni Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. |
| description |
Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci. |
| format |
article |
| author |
Julie Di Cristofaro Erwan Pennarun Stéphane Mazières Natalie M Myres Alice A Lin Shah Aga Temori Mait Metspalu Ene Metspalu Michael Witzel Roy J King Peter A Underhill Richard Villems Jacques Chiaroni |
| author_facet |
Julie Di Cristofaro Erwan Pennarun Stéphane Mazières Natalie M Myres Alice A Lin Shah Aga Temori Mait Metspalu Ene Metspalu Michael Witzel Roy J King Peter A Underhill Richard Villems Jacques Chiaroni |
| author_sort |
Julie Di Cristofaro |
| title |
Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. |
| title_short |
Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. |
| title_full |
Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. |
| title_fullStr |
Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. |
| title_full_unstemmed |
Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. |
| title_sort |
afghan hindu kush: where eurasian sub-continent gene flows converge. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/69b38235dda14810abf04c5870b36bc3 |
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