Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology

Mutations in the parkin, an ubiquitin ligase, are linked to Parkinson’s disease. Here the authors show that synaptotagmin-11 is a parkin substrate and that its upregulation affects dopamine release, triggers degeneration, and causes motor impairment.

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Autores principales:	Changhe Wang, Xinjiang Kang, Li Zhou, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, Zhuan Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69b97946de444a3499ffefdcfb3fdb59
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spelling	oai:doaj.org-article:69b97946de444a3499ffefdcfb3fdb592021-12-02T17:33:03ZSynaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology10.1038/s41467-017-02593-y2041-1723https://doaj.org/article/69b97946de444a3499ffefdcfb3fdb592018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02593-yhttps://doaj.org/toc/2041-1723Mutations in the parkin, an ubiquitin ligase, are linked to Parkinson’s disease. Here the authors show that synaptotagmin-11 is a parkin substrate and that its upregulation affects dopamine release, triggers degeneration, and causes motor impairment.Changhe WangXinjiang KangLi ZhouZuying ChaiQihui WuRong HuangHuadong XuMeiqin HuXiaoxuan SunSuhua SunJie LiRuiying JiaoPanli ZuoLianghong ZhengZhenyu YueZhuan ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changhe Wang Xinjiang Kang Li Zhou Zuying Chai Qihui Wu Rong Huang Huadong Xu Meiqin Hu Xiaoxuan Sun Suhua Sun Jie Li Ruiying Jiao Panli Zuo Lianghong Zheng Zhenyu Yue Zhuan Zhou Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
description	Mutations in the parkin, an ubiquitin ligase, are linked to Parkinson’s disease. Here the authors show that synaptotagmin-11 is a parkin substrate and that its upregulation affects dopamine release, triggers degeneration, and causes motor impairment.
format	article
author	Changhe Wang Xinjiang Kang Li Zhou Zuying Chai Qihui Wu Rong Huang Huadong Xu Meiqin Hu Xiaoxuan Sun Suhua Sun Jie Li Ruiying Jiao Panli Zuo Lianghong Zheng Zhenyu Yue Zhuan Zhou
author_facet	Changhe Wang Xinjiang Kang Li Zhou Zuying Chai Qihui Wu Rong Huang Huadong Xu Meiqin Hu Xiaoxuan Sun Suhua Sun Jie Li Ruiying Jiao Panli Zuo Lianghong Zheng Zhenyu Yue Zhuan Zhou
author_sort	Changhe Wang
title	Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
title_short	Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
title_full	Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
title_fullStr	Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
title_full_unstemmed	Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
title_sort	synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and parkinson’s disease-like pathology
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/69b97946de444a3499ffefdcfb3fdb59
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Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology

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