Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis

CD47 is a promising new target in cancer immunotherapy and recently the pro-phagocytic signal SLAMF7 has been shown to have a crucial role in phagocytosis induced by CD47-blocking antibody in hematological tumors. In this study, the authors demonstrate that SLAMF7 expressed by cancer cells is not re...

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Autores principales:	Yuan He, Renee Bouwstra, Valerie R. Wiersma, Mathilde de Jong, Harm Jan Lourens, Rudolf Fehrmann, Marco de Bruyn, Emanuele Ammatuna, Gerwin Huls, Tom van Meerten, Edwin Bremer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/69bb46c6cb07419c8c3da1b05f0247bc
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spelling	oai:doaj.org-article:69bb46c6cb07419c8c3da1b05f0247bc2021-12-02T15:35:12ZCancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis10.1038/s41467-018-08013-z2041-1723https://doaj.org/article/69bb46c6cb07419c8c3da1b05f0247bc2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08013-zhttps://doaj.org/toc/2041-1723CD47 is a promising new target in cancer immunotherapy and recently the pro-phagocytic signal SLAMF7 has been shown to have a crucial role in phagocytosis induced by CD47-blocking antibody in hematological tumors. In this study, the authors demonstrate that SLAMF7 expressed by cancer cells is not required for phagocytosis suggesting that, in contrast to CD47 expression, SLAMF7 should not be used as selection criterion for CD47-targeted therapy.Yuan HeRenee BouwstraValerie R. WiersmaMathilde de JongHarm Jan LourensRudolf FehrmannMarco de BruynEmanuele AmmatunaGerwin HulsTom van MeertenEdwin BremerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan He Renee Bouwstra Valerie R. Wiersma Mathilde de Jong Harm Jan Lourens Rudolf Fehrmann Marco de Bruyn Emanuele Ammatuna Gerwin Huls Tom van Meerten Edwin Bremer Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
description	CD47 is a promising new target in cancer immunotherapy and recently the pro-phagocytic signal SLAMF7 has been shown to have a crucial role in phagocytosis induced by CD47-blocking antibody in hematological tumors. In this study, the authors demonstrate that SLAMF7 expressed by cancer cells is not required for phagocytosis suggesting that, in contrast to CD47 expression, SLAMF7 should not be used as selection criterion for CD47-targeted therapy.
format	article
author	Yuan He Renee Bouwstra Valerie R. Wiersma Mathilde de Jong Harm Jan Lourens Rudolf Fehrmann Marco de Bruyn Emanuele Ammatuna Gerwin Huls Tom van Meerten Edwin Bremer
author_facet	Yuan He Renee Bouwstra Valerie R. Wiersma Mathilde de Jong Harm Jan Lourens Rudolf Fehrmann Marco de Bruyn Emanuele Ammatuna Gerwin Huls Tom van Meerten Edwin Bremer
author_sort	Yuan He
title	Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
title_short	Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
title_full	Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
title_fullStr	Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
title_full_unstemmed	Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
title_sort	cancer cell-expressed slamf7 is not required for cd47-mediated phagocytosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/69bb46c6cb07419c8c3da1b05f0247bc
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Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis

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