Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota

Abstract Feeding drug residue-containing milk to calves is common worldwide and no information is currently available on the impact on the functional profile of the fecal microbiota. Our objective was to characterize the functional profile of the fecal microbiota of preweaned dairy calves fed raw mi...

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Autores principales:	Richard Van Vleck Pereira, Laura M. Carroll, Svetlana Lima, Carla Foditsch, Julie D. Siler, Rodrigo Carvalho Bicalho, Lorin D. Warnick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69bffb12cbb84b8990e9937b117cff29
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spelling	oai:doaj.org-article:69bffb12cbb84b8990e9937b117cff292021-12-02T15:08:17ZImpacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota10.1038/s41598-017-19021-22045-2322https://doaj.org/article/69bffb12cbb84b8990e9937b117cff292018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-19021-2https://doaj.org/toc/2045-2322Abstract Feeding drug residue-containing milk to calves is common worldwide and no information is currently available on the impact on the functional profile of the fecal microbiota. Our objective was to characterize the functional profile of the fecal microbiota of preweaned dairy calves fed raw milk with residual concentrations of antimicrobials commonly found in waste milk from birth to weaning. Calves were assigned to a controlled feeding trial being fed milk with no drug residues or milk with antibiotic residues. Fecal samples collected from each calf once a week starting at birth, prior to the first feeding in the trial, until 6 weeks of age. Antibiotic residues resulted in a significant difference in relative abundance of microbial cell functions, especially with genes linked with stress response, regulation and cell signaling, and nitrogen metabolism. These changes could directly impacts selection and dissemination of virulence and antimicrobial. Our data also identified a strong association between age in weeks and abundance of Resistance to Antibiotics and Toxic Compounds. Findings from this study support the hypothesis that drug residues, even at very low concentrations, impact the gut microbiota of calves and result in changes in the functional profile of microbial populations.Richard Van Vleck PereiraLaura M. CarrollSvetlana LimaCarla FoditschJulie D. SilerRodrigo Carvalho BicalhoLorin D. WarnickNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richard Van Vleck Pereira Laura M. Carroll Svetlana Lima Carla Foditsch Julie D. Siler Rodrigo Carvalho Bicalho Lorin D. Warnick Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota
description	Abstract Feeding drug residue-containing milk to calves is common worldwide and no information is currently available on the impact on the functional profile of the fecal microbiota. Our objective was to characterize the functional profile of the fecal microbiota of preweaned dairy calves fed raw milk with residual concentrations of antimicrobials commonly found in waste milk from birth to weaning. Calves were assigned to a controlled feeding trial being fed milk with no drug residues or milk with antibiotic residues. Fecal samples collected from each calf once a week starting at birth, prior to the first feeding in the trial, until 6 weeks of age. Antibiotic residues resulted in a significant difference in relative abundance of microbial cell functions, especially with genes linked with stress response, regulation and cell signaling, and nitrogen metabolism. These changes could directly impacts selection and dissemination of virulence and antimicrobial. Our data also identified a strong association between age in weeks and abundance of Resistance to Antibiotics and Toxic Compounds. Findings from this study support the hypothesis that drug residues, even at very low concentrations, impact the gut microbiota of calves and result in changes in the functional profile of microbial populations.
format	article
author	Richard Van Vleck Pereira Laura M. Carroll Svetlana Lima Carla Foditsch Julie D. Siler Rodrigo Carvalho Bicalho Lorin D. Warnick
author_facet	Richard Van Vleck Pereira Laura M. Carroll Svetlana Lima Carla Foditsch Julie D. Siler Rodrigo Carvalho Bicalho Lorin D. Warnick
author_sort	Richard Van Vleck Pereira
title	Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota
title_short	Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota
title_full	Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota
title_fullStr	Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota
title_full_unstemmed	Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota
title_sort	impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/69bffb12cbb84b8990e9937b117cff29
work_keys_str_mv	AT richardvanvleckpereira impactsoffeedingpreweanedcalvesmilkcontainingdrugresiduesonthefunctionalprofileofthefecalmicrobiota AT lauramcarroll impactsoffeedingpreweanedcalvesmilkcontainingdrugresiduesonthefunctionalprofileofthefecalmicrobiota AT svetlanalima impactsoffeedingpreweanedcalvesmilkcontainingdrugresiduesonthefunctionalprofileofthefecalmicrobiota AT carlafoditsch impactsoffeedingpreweanedcalvesmilkcontainingdrugresiduesonthefunctionalprofileofthefecalmicrobiota AT juliedsiler impactsoffeedingpreweanedcalvesmilkcontainingdrugresiduesonthefunctionalprofileofthefecalmicrobiota AT rodrigocarvalhobicalho impactsoffeedingpreweanedcalvesmilkcontainingdrugresiduesonthefunctionalprofileofthefecalmicrobiota AT lorindwarnick impactsoffeedingpreweanedcalvesmilkcontainingdrugresiduesonthefunctionalprofileofthefecalmicrobiota
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Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota

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