Selective impairment of attentional networks of alerting in Wilson's disease.

Wilson's disease (WD) is typically affected by attention, which is one of the cognitive domains. The Attention Network Test (ANT) was developed to measure the functioning of the following three individual attentional networks: orienting, alerting, and executive control. The ANT has been used in...

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Autores principales:	Yongsheng Han, Fangfang Zhang, Yanghua Tian, Panpan Hu, Bo Li, Kai Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/69c0a2143c7448229bf53ca0367b5fff
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spelling	oai:doaj.org-article:69c0a2143c7448229bf53ca0367b5fff2021-11-18T08:14:50ZSelective impairment of attentional networks of alerting in Wilson's disease.1932-620310.1371/journal.pone.0100454https://doaj.org/article/69c0a2143c7448229bf53ca0367b5fff2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24949936/?tool=EBIhttps://doaj.org/toc/1932-6203Wilson's disease (WD) is typically affected by attention, which is one of the cognitive domains. The Attention Network Test (ANT) was developed to measure the functioning of the following three individual attentional networks: orienting, alerting, and executive control. The ANT has been used in a variety of neuropsychiatric conditions; however, it has not been used in WD. The aim of this study was to investigate the attentional function of WD patients, and 35 patients with early and moderate neurological WD, as well as 35 gender-, age-, and education-matched healthy controls performed the ANT. Remarkable differences between the patients and healthy controls were observed in the alerting network (p = 0.007) in contrast the differences in the orienting (p = 0.729) and executive control (p = 0.888) networks of visual attention. The mean reaction time in the ANT was significantly longer in the WD patients than in the controls (p<0.001, 0.001). In the WD patients, there was an effect specifically on the alerting domain of the attention network, whereas the orienting and executive control domains were not affected.Yongsheng HanFangfang ZhangYanghua TianPanpan HuBo LiKai WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e100454 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yongsheng Han Fangfang Zhang Yanghua Tian Panpan Hu Bo Li Kai Wang Selective impairment of attentional networks of alerting in Wilson's disease.
description	Wilson's disease (WD) is typically affected by attention, which is one of the cognitive domains. The Attention Network Test (ANT) was developed to measure the functioning of the following three individual attentional networks: orienting, alerting, and executive control. The ANT has been used in a variety of neuropsychiatric conditions; however, it has not been used in WD. The aim of this study was to investigate the attentional function of WD patients, and 35 patients with early and moderate neurological WD, as well as 35 gender-, age-, and education-matched healthy controls performed the ANT. Remarkable differences between the patients and healthy controls were observed in the alerting network (p = 0.007) in contrast the differences in the orienting (p = 0.729) and executive control (p = 0.888) networks of visual attention. The mean reaction time in the ANT was significantly longer in the WD patients than in the controls (p<0.001, 0.001). In the WD patients, there was an effect specifically on the alerting domain of the attention network, whereas the orienting and executive control domains were not affected.
format	article
author	Yongsheng Han Fangfang Zhang Yanghua Tian Panpan Hu Bo Li Kai Wang
author_facet	Yongsheng Han Fangfang Zhang Yanghua Tian Panpan Hu Bo Li Kai Wang
author_sort	Yongsheng Han
title	Selective impairment of attentional networks of alerting in Wilson's disease.
title_short	Selective impairment of attentional networks of alerting in Wilson's disease.
title_full	Selective impairment of attentional networks of alerting in Wilson's disease.
title_fullStr	Selective impairment of attentional networks of alerting in Wilson's disease.
title_full_unstemmed	Selective impairment of attentional networks of alerting in Wilson's disease.
title_sort	selective impairment of attentional networks of alerting in wilson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/69c0a2143c7448229bf53ca0367b5fff
work_keys_str_mv	AT yongshenghan selectiveimpairmentofattentionalnetworksofalertinginwilsonsdisease AT fangfangzhang selectiveimpairmentofattentionalnetworksofalertinginwilsonsdisease AT yanghuatian selectiveimpairmentofattentionalnetworksofalertinginwilsonsdisease AT panpanhu selectiveimpairmentofattentionalnetworksofalertinginwilsonsdisease AT boli selectiveimpairmentofattentionalnetworksofalertinginwilsonsdisease AT kaiwang selectiveimpairmentofattentionalnetworksofalertinginwilsonsdisease
_version_	1718421988832182272

Selective impairment of attentional networks of alerting in Wilson's disease.

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