Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study

Amare Desalegn Wolide,1 Belay Zawdie,2 Tilahun Alemayehu,3 Samuel Tadesse1 1Department of Medical Physiology, 2Department of Medical Biochemistry, 3Department of Human Anatomy, College of Health Sciences, Jimma University, Jimma, Ethiopia Background: The chronic hyperglycemia of diabetes has been as...

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Autores principales:	Wolide AD, Zawdie B, Alemayehu T, Tadesse S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Diabetes Ferritin Trace metal elements Hyperglycemia Insulin. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/69c330b3238c4603b734ee1a5aa10d3c
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spelling	oai:doaj.org-article:69c330b3238c4603b734ee1a5aa10d3c2021-12-02T11:28:36ZEvaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study1178-7007https://doaj.org/article/69c330b3238c4603b734ee1a5aa10d3c2016-12-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-serum-ferritin-and-some-metal-elements-in-type-2-diabete-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Amare Desalegn Wolide,1 Belay Zawdie,2 Tilahun Alemayehu,3 Samuel Tadesse1 1Department of Medical Physiology, 2Department of Medical Biochemistry, 3Department of Human Anatomy, College of Health Sciences, Jimma University, Jimma, Ethiopia Background: The chronic hyperglycemia of diabetes has been associated with an imbalance of some trace metal elements in the blood sample of type 2 diabetes patients. Aim: To evaluate the status of serum ferritin and some selected metal elements among type 2 diabetes mellitus (T2DM) patients. Methods: Facility-based comparative cross-sectional study was conducted from February 15, 2015 to October 30, 2015, at Jimma University Specialized Hospital, Ethiopia. A total of 428 type 2 diabetes and nondiabetes study subjects were recruited to the study. After overnight fasting, 10 mL of venous blood samples were taken for biochemical and trace metal element analysis. Data were entered into EpiData version 3.5.1 and exported to SPSS version 20 for Windows for analysis. Results: Serum concentration of Zn+2, Mg+2, Cr+3, ferritin, and Fe+3 in patients with type 2 diabetes was significantly lower (p<0.0001) than nondiabetes patients. In contrast, serum Cu+2 was significantly higher (p<0.0001) in type 2 diabetes patients than nondiabetics. In addition, significant differences were not seen in both groups with regard to serum Mn+2, Ca+2, and Po4−3. Waist-to-hip ratio (WHR), serum Fe+3, ferritin, and Mn+2 were significantly higher among oral hypoglycemic agent users of type 2 diabetes patients than the injectable insulin users. Serum Zn+2 had significant positive correlation with serum Mg+2 (r=0.738), Cr+3 (r=0.233), Ca+2 (r=0.238), and Po4−3 (r=0.222). In addition, serum Zn+2 had shown significant and negative correlation with body mass index (BMI, r=−0.331), WHR (r=−0.340), and fasting blood glucose (FBG, r=−0.186). Likewise, serum Mg+2 and Po4−3 are significantly and negatively correlated with BMI, WHR, and FBG. Conclusion: The imbalance of trace metal elements in the blood sample of diabetes is uncertain. Thus, we recommend a prospective cohort study to find out the principal factors behind the problem. Keywords: diabetes, ferritin, trace metal elements, hyperglycemia, insulin, metalWolide ADZawdie BAlemayehu TTadesse SDove Medical PressarticleDiabetesFerritinTrace metal elementsHyperglycemiaInsulin.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 9, Pp 417-424 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetes Ferritin Trace metal elements Hyperglycemia Insulin. Specialties of internal medicine RC581-951
spellingShingle	Diabetes Ferritin Trace metal elements Hyperglycemia Insulin. Specialties of internal medicine RC581-951 Wolide AD Zawdie B Alemayehu T Tadesse S Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study
description	Amare Desalegn Wolide,1 Belay Zawdie,2 Tilahun Alemayehu,3 Samuel Tadesse1 1Department of Medical Physiology, 2Department of Medical Biochemistry, 3Department of Human Anatomy, College of Health Sciences, Jimma University, Jimma, Ethiopia Background: The chronic hyperglycemia of diabetes has been associated with an imbalance of some trace metal elements in the blood sample of type 2 diabetes patients. Aim: To evaluate the status of serum ferritin and some selected metal elements among type 2 diabetes mellitus (T2DM) patients. Methods: Facility-based comparative cross-sectional study was conducted from February 15, 2015 to October 30, 2015, at Jimma University Specialized Hospital, Ethiopia. A total of 428 type 2 diabetes and nondiabetes study subjects were recruited to the study. After overnight fasting, 10 mL of venous blood samples were taken for biochemical and trace metal element analysis. Data were entered into EpiData version 3.5.1 and exported to SPSS version 20 for Windows for analysis. Results: Serum concentration of Zn+2, Mg+2, Cr+3, ferritin, and Fe+3 in patients with type 2 diabetes was significantly lower (p<0.0001) than nondiabetes patients. In contrast, serum Cu+2 was significantly higher (p<0.0001) in type 2 diabetes patients than nondiabetics. In addition, significant differences were not seen in both groups with regard to serum Mn+2, Ca+2, and Po4−3. Waist-to-hip ratio (WHR), serum Fe+3, ferritin, and Mn+2 were significantly higher among oral hypoglycemic agent users of type 2 diabetes patients than the injectable insulin users. Serum Zn+2 had significant positive correlation with serum Mg+2 (r=0.738), Cr+3 (r=0.233), Ca+2 (r=0.238), and Po4−3 (r=0.222). In addition, serum Zn+2 had shown significant and negative correlation with body mass index (BMI, r=−0.331), WHR (r=−0.340), and fasting blood glucose (FBG, r=−0.186). Likewise, serum Mg+2 and Po4−3 are significantly and negatively correlated with BMI, WHR, and FBG. Conclusion: The imbalance of trace metal elements in the blood sample of diabetes is uncertain. Thus, we recommend a prospective cohort study to find out the principal factors behind the problem. Keywords: diabetes, ferritin, trace metal elements, hyperglycemia, insulin, metal
format	article
author	Wolide AD Zawdie B Alemayehu T Tadesse S
author_facet	Wolide AD Zawdie B Alemayehu T Tadesse S
author_sort	Wolide AD
title	Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study
title_short	Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study
title_full	Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study
title_fullStr	Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study
title_full_unstemmed	Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study
title_sort	evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/69c330b3238c4603b734ee1a5aa10d3c
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Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study

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